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Plague’s Partners in Crime

Published byUtami Widyawati Lesmono Modified over 5 years ago

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Presentation on theme: "Plague’s Partners in Crime"— Presentation transcript:

1 Plague’s Partners in Crime
Kimberly M. Davis, Ralph R. Isberg  Immunity  Volume 41, Issue 3, Pages (September 2014) DOI: /j.immuni Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 After Inoculation, Infected DCs Are Recruited from the Periphery to Primary LNs via CCR7 and S1PRs, where They Produce CCL2 and Recruit Monocytes via CCR2 and S1PRs to Primary dLNs Infected monocytes transport bacteria intracellularly to secondary LNs, where they begin to replicate extracellularly and spread to the bloodstream and tissue sites. Trafficking of infected monocytes (CX3CR1+) between primary and secondary LNs via the receptor S1P1 is particularly important in disease progression. Immunity  , DOI: ( /j.immuni ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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