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Pediatric Heart Transplantation for Congenital and Restrictive Cardiomyopathy  Bari Murtuza, MD, PhD, Matthew Fenton, MD, Michael Burch, MD, Arun Gupta,

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Presentation on theme: "Pediatric Heart Transplantation for Congenital and Restrictive Cardiomyopathy  Bari Murtuza, MD, PhD, Matthew Fenton, MD, Michael Burch, MD, Arun Gupta,"— Presentation transcript:

1 Pediatric Heart Transplantation for Congenital and Restrictive Cardiomyopathy 
Bari Murtuza, MD, PhD, Matthew Fenton, MD, Michael Burch, MD, Arun Gupta, BS, Nagarajan Muthialu, FRCS, Martin J. Elliott, MD, Tain-Yen Hsia, MD, Victor T. Tsang, MD, FRCS, Martin Kostolny, MD  The Annals of Thoracic Surgery  Volume 95, Issue 5, Pages (May 2013) DOI: /j.athoracsur Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Mechanical circulatory support in transplant recipients. (A) Extracorporeal membrane oxygenation (ECMO) in patients before and after orthotopic heart transplantation (OHT) by diagnostic group. The most notable difference is in proportion of pre-OHT support required in patients with dilatated cardiomyopathy (DCM) compared with those with congenital heart disease (CHD) and patients with restrictive cardiomyopathy (RCM). (B) Ventricular assist device (VAD) support before and after OHT by diagnostic group. As with ECMO, the DCM cohort is remarkable for its high proportion of patients requiring preoperative VAD support. (0 = no support; 1 = support before OHT; 2 = support after OHT; 3 = support before and after OHT) (CCHD = critical congenital heart disease.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Overall Kaplan-Meier survival curves for entire study cohort. (CHD = congenital heart disease; CCHD = critical congenital heart disease; DCM = dilatated cardiomyopathy; RCM = restrictive cardiomyopathy.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Kaplan-Meier survival curves in patients with congenital heart disease (CHD) with either Glenn or Fontan circulations. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Kaplan-Meier survival curves according to antibody status. (A) There was significantly better survival in patients with calculated reaction frequency (CRF) values less than 50 compared with those with higher CRF values. (B) Survival analysis according to non–donor-specific antibody (NDSA) status revealed poorer survival in patients with NDSA-positive status. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

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