Presentation is loading. Please wait.

Presentation is loading. Please wait.

John S. Ikonomidis, MD, PhD, Charlotte R. Ivey, BS, Jason B

Published byScot Davidson Modified over 5 years ago

Similar presentations

Presentation on theme: "John S. Ikonomidis, MD, PhD, Charlotte R. Ivey, BS, Jason B"— Presentation transcript:

1 Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease 
John S. Ikonomidis, MD, PhD, Charlotte R. Ivey, BS, Jason B. Wheeler, MD, Adam W. Akerman, BS, Allison Rice, BS, Risha K. Patel, BS, Robert E. Stroud, MS, Asad A. Shah, MD, Chad G. Hughes, MD, Giovanni Ferrari, PhD, Rupak Mukherjee, PhD, Jeffrey A. Jones, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 145, Issue 5, Pages (May 2013) DOI: /j.jtcvs Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Aortic tissue and plasma analysis for microRNAs (miRs), matrix metalloproteinases (MMPs) and tissue inhibitors of matalloproteinases (TIMPs), comparing ascending thoracic aortic aneurysms (TAAs) associated with bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) from normal aortic samples (dashed line). Significant differences were observed between the BAV and TAV groups, and between the aneurysm groups and normal aorta group. *P < .05 from normal aorta. †P < .05 from BAV. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Linear regression analysis identifying significant relationships between analyte tissue and plasma levels. Significant relationships were found for matrix metalloproteinase (MMP) 8, tissue inhibitor of metalloproteinase (TIMP) 1, TIMP-3, and TIMP-4. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Receiver operating characteristic curves to assess plasma aneurysm predictability. Inclusion of plasma analytes using forward stepwise variable selection resulted in different combinations for thoracic aortic aneurism (TAA) in general (top), bicuspid aortic valve-associated TAAs (middle), and tricuspid aortic valve-associated TAAs (bottom) providing high area-under-the curve (AUC) values, indicating high sensitivity and specificity. MMP, Matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase; miR, microRNA. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

5 Appendix Figure 1 Relative proteolytic balance expressed as the ratio of matrix metalloproteinase (MMP) abundance to a composite tissue inhibitor of metalloproteinase (TIMP) score composed of the sum of TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Different profiles of proteolytic balance were observed for the bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) groups. *P < .05 from normal aorta. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

Download ppt "John S. Ikonomidis, MD, PhD, Charlotte R. Ivey, BS, Jason B"

Similar presentations

Resection of ascending aortic aneurysm without use of an interposition aortic graft John S. Ikonomidis, MD, PhD, FRCS(C), Abe DeAnda, MD, D.Craig Miller,

Resection of ascending aortic aneurysm without use of an interposition aortic graft John S. Ikonomidis, MD, PhD, FRCS(C), Abe DeAnda, MD, D.Craig Miller,
Tubular heart valves: A new tissue prosthesis design—Preclinical evaluation of the 3F aortic bioprosthesis James L. Cox, MD, Niv Ad, MD, Keith Myers, BS,

Tubular heart valves: A new tissue prosthesis design—Preclinical evaluation of the 3F aortic bioprosthesis James L. Cox, MD, Niv Ad, MD, Keith Myers, BS,
Transcatheter aortic valve replacement in patients with severe aortic stenosis who are at high risk for surgical complications: Summary assessment of.

Transcatheter aortic valve replacement in patients with severe aortic stenosis who are at high risk for surgical complications: Summary assessment of.
Max B. Mitchell, MD  The Journal of Thoracic and Cardiovascular Surgery 

Max B. Mitchell, MD  The Journal of Thoracic and Cardiovascular Surgery 
Of mice and men and surgical transcatheter aortic valve insertion

Of mice and men and surgical transcatheter aortic valve insertion
Manuel J. Antunes, MD, PhD, DSc 

Manuel J. Antunes, MD, PhD, DSc 
Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm.

Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm.
Response of plasma matrix metalloproteinases and tissue inhibitor of metalloproteinases to stent-graft surgery for descending thoracic aortic aneurysms 

Response of plasma matrix metalloproteinases and tissue inhibitor of metalloproteinases to stent-graft surgery for descending thoracic aortic aneurysms 
Surgery for congenital diseases of the aorta

Surgery for congenital diseases of the aorta
Management of the moderately dilated sinus of Valsalva: To cut or not to cut?  Rita Karianna Milewski, MD, PhD, Andreas Habertheuer, MD, PhD, Joseph E.

Management of the moderately dilated sinus of Valsalva: To cut or not to cut?  Rita Karianna Milewski, MD, PhD, Andreas Habertheuer, MD, PhD, Joseph E.
Jeffrey A. Jones, PhD, Juozas A. Zavadzkas, MD, Eileen I

Jeffrey A. Jones, PhD, Juozas A. Zavadzkas, MD, Eileen I
Bicuspid aortic valves undergo excessive strain during opening: A simulation study  Susumu Katayama, MSc, Nobuyuki Umetani, MEnv, Toshiaki Hisada, PhD,

Bicuspid aortic valves undergo excessive strain during opening: A simulation study  Susumu Katayama, MSc, Nobuyuki Umetani, MEnv, Toshiaki Hisada, PhD,
Long-term prognosis of ascending aortic aneurysm after aortic valve replacement for bicuspid versus tricuspid aortic valve stenosis  Evaldas Girdauskas,

Long-term prognosis of ascending aortic aneurysm after aortic valve replacement for bicuspid versus tricuspid aortic valve stenosis  Evaldas Girdauskas,
Replacement of the ascending aorta in bicuspid aortic valve disease: Where do we draw the line?  Thoralf M. Sundt, MD  The Journal of Thoracic and Cardiovascular.

Replacement of the ascending aorta in bicuspid aortic valve disease: Where do we draw the line?  Thoralf M. Sundt, MD  The Journal of Thoracic and Cardiovascular.
Stephen H. McKellar, MD, David J

Stephen H. McKellar, MD, David J
Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia–reperfusion: Relationship to interstitial microRNA dynamics and.

Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia–reperfusion: Relationship to interstitial microRNA dynamics and.
Rate of increase in serum lactate level risk-stratifies infants after surgery for congenital heart disease  Kurt R. Schumacher, MS, MD, Rebecca A. Reichel,

Rate of increase in serum lactate level risk-stratifies infants after surgery for congenital heart disease  Kurt R. Schumacher, MS, MD, Rebecca A. Reichel,
Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic.

Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic.
Scott A. Hittinger, MD, Tom P. Theruvath, MD, PhD, John S

Scott A. Hittinger, MD, Tom P. Theruvath, MD, PhD, John S
Bicuspid aortic valve aortopathy: One size fits all?

Bicuspid aortic valve aortopathy: One size fits all?

Similar presentations

Ads by Google