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Common Temporal Identity Factors Regulate Neuronal Diversity in Fly Ventral Nerve Cord and Mouse Retina  Nikolaos Konstantinides, Anthony M. Rossi, Claude.

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Presentation on theme: "Common Temporal Identity Factors Regulate Neuronal Diversity in Fly Ventral Nerve Cord and Mouse Retina  Nikolaos Konstantinides, Anthony M. Rossi, Claude."— Presentation transcript:

1 Common Temporal Identity Factors Regulate Neuronal Diversity in Fly Ventral Nerve Cord and Mouse Retina  Nikolaos Konstantinides, Anthony M. Rossi, Claude Desplan  Neuron  Volume 85, Issue 3, Pages (February 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Temporal Patterning in Mouse and Fly
(A) Retinal cell types are born sequentially. Retinal progenitor cells (RPCs) first express Ikzf1 to specify early-born cell types (blue) before switching to express Casz1 to identify later-born retinal cell types (purple). Although the birth of cones (green) overlaps with other early-born cell types, Ikzf1 does not specify cone identity. In addition, Casz1 does not specify last-born Müller Glia (aqua), suggesting an additional temporal identity window. RGC, retinal ganglion cells; AC, amacrine cells; HC, horizontal cells; BC, bipolar cells; MG, Müller Glia. (B) Known temporal sequences in fly and mouse. Mattar et al. (2015) identified a regulatory interaction between Ikzf1/Hb and Casz1/Cas in mouse RPCs that is similar in Drosophila VNC neuroblasts. Neuron  , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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