Presentation is loading. Please wait.

Presentation is loading. Please wait.

TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice  Susumu Nakae, PhD, Carolina Lunderius, PhD,

Published byMatyáš Novák Modified over 5 years ago

Similar presentations

Presentation on theme: "TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice  Susumu Nakae, PhD, Carolina Lunderius, PhD,"— Presentation transcript:

1 TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice  Susumu Nakae, PhD, Carolina Lunderius, PhD, Lien H. Ho, PhD, Beatrix Schäfer, PhD, Mindy Tsai, DMSc, Stephen J. Galli, MD  Journal of Allergy and Clinical Immunology  Volume 119, Issue 3, Pages (March 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Reduced expression of antigen induced-AHR after OVA immunization without alum in C57BL/6J-TNF−/− mice. Airway responses to methacholine were measured 24 hours after the last intranasal OVA or PBS challenge. ∗P < .01 for PBS-challenged vs OVA-challenged mice; †P < .01 for OVA-challenged TNF−/− vs wild-type mice. Data were pooled from at least 2 independent experiments, each of which gave similar results. PBS-treated mice, n= 5-8/group; OVA-challenged mice, n = 12-16/group. B, Baseline. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Histologic analysis of lungs from C57BL/6J-TNF−/− vs wild-type mice. Lung sections (hematoxylin and eosin–stained) obtained 24 hours after the last intranasal OVA or PBS challenge in mice immunized with OVA without alum. Striking infiltrates of inflammatory cells (∗) are present near the airways in OVA-sensitized, OVA-challenged mice (C-F) but not in PBS-challenged mice (A and B). A-D, ×100, scale bars = 200 μm; E and F, ×400, scale bars = 50 μm. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Reduced numbers of leukocytes in BALF; reduced lung levels of MPO, EPO, IL-4, IL-5, and IL-17; and reduced serum levels of OVA-specific IgG1 and IgE in C57BL/6J-TNF−/− mice 24 hours after OVA challenge in mice immunized with OVA without alum. A, Cell numbers in BALFs from the same mice shown in Fig 1. B, MPO and EPO levels in lung homogenates. C, IL-4, IL-5, IL-17, and IFN-γ levels in lung homogenates. D, OVA-specific IgG1 and IgE levels in sera. ∗P < .01 for comparisons shown in brackets; †P < .05 vs values for the corresponding PBS-treated mice. PBS-treated mice, n = 5-8/group; OVA-challenged mice, n = 12-16/group. B, Baseline. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Airway responses to methacholine and BALF leukocytes 24 hours after the last intranasal OVA or PBS challenge in C57BL/6J wild-type, TNFR1−/−, TNFR2−/−, and memTNFΔ/Δ mice immunized with OVA without alum. A, Airway responses to methacholine. ∗P < .01 for PBS-treated vs the corresponding OVA-challenged mice; †P < .05 for OVA-treated wild-type vs TNFR1−/− , TNFR2−/−, or memTNFΔ/Δ mice. Data are pooled from the 3 independent experiments that we performed, each of which gave similar results. B, Baseline. B, Cell number in BALFs collected from the same mice shown in A. ∗P < .01 for PBS-treated vs the corresponding OVA-challenged mice; †P < .05 for OVA-treated wild-type vs TNFR1−/−, TNFR2−/−, or memTNFΔ/Δ mice. PBS-treated mice, n = 8-10/group; OVA-treated mice, n = 10-16/group. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice  Susumu Nakae, PhD, Carolina Lunderius, PhD,"

Similar presentations

Exposure to allergen and diesel exhaust particles potentiates secondary allergen- specific memory responses, promoting asthma susceptibility  Eric B. Brandt,

Exposure to allergen and diesel exhaust particles potentiates secondary allergen- specific memory responses, promoting asthma susceptibility  Eric B. Brandt,
Platelets play important roles in the late phase of the immediate hypersensitivity reaction  Risa Tamagawa-Mineoka, MD, PhD, Norito Katoh, MD, PhD, Saburo.

Platelets play important roles in the late phase of the immediate hypersensitivity reaction  Risa Tamagawa-Mineoka, MD, PhD, Norito Katoh, MD, PhD, Saburo.
Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation  Kathrin Straubinger,

Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation  Kathrin Straubinger,
IL-4 induces IL-13–independent allergic airway inflammation

IL-4 induces IL-13–independent allergic airway inflammation
Weiguo Chen, PhD, Umasundari Sivaprasad, PhD, Aaron M

Weiguo Chen, PhD, Umasundari Sivaprasad, PhD, Aaron M
Effective prevention and therapy of experimental allergic asthma using a GATA-3– specific DNAzyme  Serdar Sel, MD, Michael Wegmann, PhD, Tanja Dicke, MSc,

Effective prevention and therapy of experimental allergic asthma using a GATA-3– specific DNAzyme  Serdar Sel, MD, Michael Wegmann, PhD, Tanja Dicke, MSc,
The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.
The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.
Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma  Tobias Polte, PhD, Christian.

Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma  Tobias Polte, PhD, Christian.
Interferon response factor 3 is essential for house dust mite–induced airway allergy  Thomas Marichal, DVM, Denis Bedoret, DVM, PhD, Claire Mesnil, DVM,

Interferon response factor 3 is essential for house dust mite–induced airway allergy  Thomas Marichal, DVM, Denis Bedoret, DVM, PhD, Claire Mesnil, DVM,
Selective control of SIRP-α–positive airway dendritic cell trafficking through CD47 is critical for the development of TH2-mediated allergic inflammation 

Selective control of SIRP-α–positive airway dendritic cell trafficking through CD47 is critical for the development of TH2-mediated allergic inflammation 
Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation  Yuki Nakamura,

Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation  Yuki Nakamura,
Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity  Jillian L. Barlow, PhD, Agustin Bellosi,

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity  Jillian L. Barlow, PhD, Agustin Bellosi,
Expression of IL-4 receptor α on smooth muscle cells is not necessary for development of experimental allergic asthma  Frank Kirstein, PhD, William G.C.

Expression of IL-4 receptor α on smooth muscle cells is not necessary for development of experimental allergic asthma  Frank Kirstein, PhD, William G.C.
Frank Kirstein, PhD, Natalie E

Frank Kirstein, PhD, Natalie E
Exposure to allergen and diesel exhaust particles potentiates secondary allergen- specific memory responses, promoting asthma susceptibility  Eric B. Brandt,

Exposure to allergen and diesel exhaust particles potentiates secondary allergen- specific memory responses, promoting asthma susceptibility  Eric B. Brandt,
Nazanin Farhadi, MSc, Laura Lambert, BA, Chiara Triulzi, PhD, Peter J

Nazanin Farhadi, MSc, Laura Lambert, BA, Chiara Triulzi, PhD, Peter J
IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs  Chien-Chang Chen, PhD, Takao Kobayashi, PhD, Koji Iijima,

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs  Chien-Chang Chen, PhD, Takao Kobayashi, PhD, Koji Iijima,
Restoration of T-box–containing protein expressed in T cells protects against allergen- induced asthma  Jung Won Park, MD, Hyun Jung Min, MS, Jung Ho Sohn,

Restoration of T-box–containing protein expressed in T cells protects against allergen- induced asthma  Jung Won Park, MD, Hyun Jung Min, MS, Jung Ho Sohn,
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2- inducing allergen exposures  Matthew J. Gold, BSc, Frann Antignano,

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2- inducing allergen exposures  Matthew J. Gold, BSc, Frann Antignano,

Similar presentations

Ads by Google