1. PSEN1 modules in AD and aging.
PSEN1 modules in AD and aging. A, B, VisANT was used to create network depictions as in Figure 3 for the AD network (A), where PSEN1 is a hub, and aging network (B), where PSEN1 is not a hub. The local networks of PSEN1 are similar in AD and aging, however, as seven genes (including the hubs ENPP2 and LIPA) overlap between both PSEN1 local networks (hypergeometric probability; p < 10−8). Both hub genes (large nodes) and canonical oligodendrocyte genes are labeled, and all lines represent positive gene–gene correlations. As with Figure 3, node positions and line lengths are chosen to highlight network structure and do not have any biological meaning.
©2008 by Society for Neuroscience