Presentation is loading. Please wait.

Presentation is loading. Please wait.

European Urology Oncology

Published byVratislav Kašpar Modified over 5 years ago

Similar presentations

Presentation on theme: "European Urology Oncology"— Presentation transcript:

1 European Urology Oncology
Diagnostic DNA Methylation Biomarkers for Renal Cell Carcinoma: A Systematic Review  Kim Lommen, Nathalie Vaes, Maureen J. Aarts, Joep G. van Roermund, Leo J. Schouten, Egbert Oosterwijk, Veerle Melotte, Vivianne C. Tjan-Heijnen, Manon van Engeland, Kim M. Smits  European Urology Oncology  DOI: /j.euo Copyright © 2019 The Authors Terms and Conditions

2 Fig. 1 PRISMA flow diagram visualising the study selection process. PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses. European Urology Oncology DOI: ( /j.euo ) Copyright © 2019 The Authors Terms and Conditions

3 Fig. 2 Sum score of all articles per STARD item. STARD = Standards for Reporting of Diagnostic Accuracy Studies. European Urology Oncology DOI: ( /j.euo ) Copyright © 2019 The Authors Terms and Conditions

4 Fig. 3 Forest plots of diagnostic RCC methylation markers that are independently validated in at least two studies. Forest plots of genomic location, sensitivity, and specificity associated with RCC diagnosis for (A) APAF1, (B) APC, (C) CDH1, (D) CDKN2A (p14), (E) CDKN2A (p16), (F) DAPK1, (G) FHIT, (H) GSTP1, (I) MGMT, (J) PTGS2, (K) RARb2, (L) RASSF1A, (M) TCF21, (N) TIMP3, and (O) VHL and corresponding LoE. ccRCC = clear cell renal cell carcinoma; chRCC = chromophobe renal cell carcinoma; CI = confidence interval; LoE = level of evidence; MSP = methylation specific polymerase chain reaction; n/a = not available; pRCC = papillary renal cell carcinoma; qMSP = quantitative methylation specific polymerase chain reaction; qPCR = quantitative polymerase chain reaction; RCC = renal cell carcinoma. a Sensitivities and specificities calculated from percentage of methylated samples. b Actual sensitivities and specificities. European Urology Oncology DOI: ( /j.euo ) Copyright © 2019 The Authors Terms and Conditions

5 Fig. 4 Independently validated markers known to be involved or methylated in several human cancers. European Urology Oncology DOI: ( /j.euo ) Copyright © 2019 The Authors Terms and Conditions

Download ppt "European Urology Oncology"

Similar presentations

Critical Reviews in Oncology / Hematology

Critical Reviews in Oncology / Hematology
Volume 70, Issue 6, Pages (December 2016)

Volume 70, Issue 6, Pages (December 2016)
European Urology Focus

European Urology Focus
Systematic Review of the Efficacy and Safety of High-Intensity Focussed Ultrasound for the Primary and Salvage Treatment of Prostate Cancer  Marisa Warmuth,

Systematic Review of the Efficacy and Safety of High-Intensity Focussed Ultrasound for the Primary and Salvage Treatment of Prostate Cancer  Marisa Warmuth,
The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks  Marcus G.

The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks  Marcus G.
Volume 70, Issue 1, Pages (July 2016)

Volume 70, Issue 1, Pages (July 2016)
Volume 67, Issue 4, Pages (April 2015)

Volume 67, Issue 4, Pages (April 2015)
Paravertebral block in paediatric abdominal surgery'a systematic review and meta- analysis of randomized trials  E.A. Page, K.L. Taylor  British Journal.

Paravertebral block in paediatric abdominal surgery'a systematic review and meta- analysis of randomized trials  E.A. Page, K.L. Taylor  British Journal.
Courtney J. Warner, MD, MS, Spencer W. Greaves, MPH, Robin J

Courtney J. Warner, MD, MS, Spencer W. Greaves, MPH, Robin J
Masatsugu Hamaji, MD, Syed Osman Ali, MD, Bryan M. Burt, MD 

Masatsugu Hamaji, MD, Syed Osman Ali, MD, Bryan M. Burt, MD 
Performance of screening questionnaires for obstructive sleep apnea during pregnancy: A systematic review and meta-analysis  Visasiri Tantrakul, Pawin.

Performance of screening questionnaires for obstructive sleep apnea during pregnancy: A systematic review and meta-analysis  Visasiri Tantrakul, Pawin.
CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non–Small-Cell Lung Cancer  Kit W. Tam, MD, MHS,

CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non–Small-Cell Lung Cancer  Kit W. Tam, MD, MHS,
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart summarising the process for the identification of eligible studies.

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart summarising the process for the identification of eligible studies.
Systematic Review of the Management of Local Kidney Cancer Relapse

Systematic Review of the Management of Local Kidney Cancer Relapse
Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration- resistant Prostate Cancer in the Era of Precision Oncology  Philipp.

Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration- resistant Prostate Cancer in the Era of Precision Oncology  Philipp.
Cerebrospinal-fluid drain-related complications in patients undergoing open and endovascular repairs of thoracic and thoraco-abdominal aortic pathologies:

Cerebrospinal-fluid drain-related complications in patients undergoing open and endovascular repairs of thoracic and thoraco-abdominal aortic pathologies:
Volume 71, Issue 4, Pages (April 2017)

Volume 71, Issue 4, Pages (April 2017)
Hants Williams, PhD (C), BSN, RN, Paula Tanabe, PhD, RN, FAEN, FAAN 

Hants Williams, PhD (C), BSN, RN, Paula Tanabe, PhD, RN, FAEN, FAAN 
The Role of Surgery in Metastatic Bladder Cancer: A Systematic Review

The Role of Surgery in Metastatic Bladder Cancer: A Systematic Review
The Potential of MicroRNAs as Prostate Cancer Biomarkers

The Potential of MicroRNAs as Prostate Cancer Biomarkers

Similar presentations

Ads by Google