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This Month in Gastroenterology

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Presentation on theme: "This Month in Gastroenterology"— Presentation transcript:

1 This Month in Gastroenterology
Jan Tack, John M. Carethers  Gastroenterology  Volume 132, Issue 5, Pages (May 2007) DOI: /j.gastro Copyright © 2007 American Gastroenterological Association Institute Terms and Conditions

2 Figure 1 Arg381Gln allele odds ratios (95% confidence intervals) in Crohn’s disease and in ulcerative colitis. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 American Gastroenterological Association Institute Terms and Conditions

3 Figure 2 (A) Proportion of patients with a clinical response at various time points. (B) Proportion of patients in remission at various time points. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 American Gastroenterological Association Institute Terms and Conditions

4 Figure 3 GGT-deficient H pylori mutants fail to inhibit lymphocyte proliferation. (A) Cell proliferation of stimulated peripheral blood mononuclear cells in the presence or absence of indicated H pylori supernatants was determined by 3H-thymidine incorporation assay. (B) GGT phenotype of constructed knock-out strains was confirmed by enzyme activity assay and immunoblotting using a polyclonal antibody raised against the large GGT subunit. For immunoblotting, 30 μg protein of H pylori supernatants were used. Immunoblotting with anti-VacA antibody served as a loading control. Data represent mean ± SD of 3 independent experiments. *P < .001 as determined by Student t test were considered significant. WT, wild type. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 American Gastroenterological Association Institute Terms and Conditions

5 Figure 4 Oderants stimulate serotonin release by enterochromaffin BON cells. BON cells were incubated for 15 minutes in serum-free medium with oderant. Serotonin release was measured in the culture supernatant by a serotonin enzyme immunoassay kit (ELISA). Concentration-dependent serotonin release by BON cells was triggered by thymol, but not phenol. P values correspond to Student–Newman–Keuls test. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2007 American Gastroenterological Association Institute Terms and Conditions


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