1. Managing Syphilis in HIV Co-infected Patients: A Case-Based Approach

2. Managing Syphilis in HIV-Coinfected Patients: A Case-Based Approach

4. CME Information

5. Nursing and Pharmacy Credits

6. Evaluations will be available in your IAS-USA “My Activities” page by 5 pm PT today. See the IAS–USA website for instructions on claiming CME, pharmacy, nursing, or pharmacotherapy credits, or a certificate of participation.

7. Grant Support for this Webinar

8. Navigating the Webinar

9. Poll 1

10. Poll 2

11. Poll 3

12. Managing Syphilis in HIV-Coinfected Patients: A Case-Based Approach

13. Financial Relationships With Commercial Entities

14. Learning Objectives

15. Pretest Question 1

16. Pretest Question 2

17. Epidemiology: Who’s at risk?

18. Where we were in 1999…

19. Syphilis: The MSM epidemic

20. Syphilis: The heterosexual epidemic

21. The intersection of epidemics: Drug use and heterosexual syphilis transmission

22. Congenital syphilis: A failure of public health

23. The Solution

24. So why are we failing?

25. So why are we failing?

26. PLWH: Syphilis Screening Recommendations

27. Epidemiology: Implications

28. Management

29. The Natural History of Syphilis

30. RJ

31. RJ

32. RJ: Laboratory Results

33. RJ: What is the clinical diagnosis?

34. Clinical Manifestations of Syphilis

35. Syphilitic Hepatitis

36. Serological tests for syphilis

37. Testing: The Reverse Sequence Algorithm

38. Management: Antimicrobial therapy

39. But what about a pregnant woman with penicillin allergy?

40. Summary: Treatment Recommendations

42. RJ: Need for CSF examination

43. CSF Examination in Neurologically Asymptomatic HIV+ Persons with Syphilis?

44. RJ

45. Patient NN

46. Patient NN

47. NN: Diagnoses

49. Neurosyphilis

50. FYI- Ocular Syphilis

51. FYI- Otosyphilis

52. Need for a CSF Examination: A Summary

53. Neurosyphilis: Questions to Ask

54. Ocular Syphilis: Questions to Ask

55. Otic Syphilis: Questions to Ask

56. Patient NN: CSF Examination

57. Are follow-up CSF Exams Necessary in Persons Treated Appropriately for Neurosyphilis?

58. Patient NN: Summary

59. Let’s go back to our patient RJ…

60. RJ

61. What is the appropriate response to RJ’s RPR titers that have not declined appropriately?

62. Does the serofast state predict poor clinical outcomes?

63. Patient RJ

64. Does additional antimicrobial therapy improve serological outcomes?

65. Summary: What I do with asymptomatic patients who experience an inadequate serological response:

66. RJ

67. Would you restart treatment over again?

68. RJ

70. Syphilis Control: Doxycycline?

71. Syphilis PrEP & PEP: Pros & Cons

72. Syphilis PrEP/PEP

73. Syphilis: Take-Home Messages

74. Thank you

77. Additional Resources

78. Posttest Question #1

79. Posttest Question #2

80. Question-and-Answer

82. Evaluations will be available in your IAS-USA “My Activities” page by 5 pm PT today. See the IAS–USA website for instructions on claiming CME, pharmacy, nursing, or pharmacotherapy credits, or a certificate of participation.

83. Final Poll

86. Thank You