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Mike Fainzilber, Jeffery L. Twiss  Neuron 

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Presentation on theme: "Mike Fainzilber, Jeffery L. Twiss  Neuron "— Presentation transcript:

1 Tracking in the Wlds—The Hunting of the SIRT and the Luring of the Draper 
Mike Fainzilber, Jeffery L. Twiss  Neuron  Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Axonal Protection by the Wlds Gene Product
(A) Schematic of mouse Wlds fusion protein structure (GenBank accession # AAG17285). Amino acid residue numbers relative to Ube4b and NMNAT-1 are shown. (B) Neuron with lesioned axon and surrounding glial cells. Mechanisms autonomous to the axon, such as surface exposure of an unknown “ligand X,” trigger glial cell activation through a process that requires draper and ced6 expression in the glia. The Wlds protein prevents this axonal triggering of glial engulfment, thereby delaying Wallerian degeneration. Neuron  , DOI: ( /j.neuron ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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