1. Fig. 3. Effects of SFN in mice with diet-induced diabetes.
Effects of SFN in mice with diet-induced diabetes. (A) IPGTT in male C57BL/6J mice fed a low-fat control diet or 60% HFD for 14 weeks treated with vehicle or SFN (0.5 or 10 mg/kg per day) for 4 weeks (n = 7 to 8 in each of the HFD groups, n = 5 to 6 in each of the control diet groups). (B) IPITT data from the mice in (A). (C) Triglyceride content in extracted liver tissue from the mice treated as in (A). (D) Gluconeogenetic rate in male C57BL/6J mice fed a 60% HFD for 12 weeks and treated with vehicle or SFN (10 mg/kg per day) for 4 weeks (n = 8 per group). The bars show data from the entire groups (average weight 40 ± 2 g for vehicle-treated and 39 ± 1 g for SFN-treated) as well as data for the three mice in each group with the highest body weight (heavy; weight of 42, 42, and 47 g for vehicle-treated and 39, 40, and 48 g for SFN-treated compared to an average weight of 38 ± 1 g for vehicle-treated and 37 ± 0.2 g for SFN-treated nonheavy mice). (E) Rate of disappearance of glucose (Rd) during clamp, reflecting whole-body insulin-stimulated glucose uptake, for the same mice as in (D). Data are means ± SEM. *P < 0.05; **P < 0.01.
Annika S. Axelsson et al., Sci Transl Med 2017;9:eaah4477
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