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Fixed-combination, low-dose, triple-pill antihypertensive medication versus usual care in patients with mild-to-moderate hypertension in Sri Lanka: a within-trial and modelled economic evaluation of the TRIUMPH trial Thomas Lung, PhD, Prof Stephen Jan, PhD, Prof H Asita de Silva, PhD, Rama Guggilla, MMeD, Pallab K Maulik, PhD, Nitish Naik, MD, Prof Anushka Patel, PhD, Prof Arjuna P de Silva, MD, Prof Senaka Rajapakse, PhD, Gotabhaya Ranasinghe, MD, Dorairaj Prabhakaran, MD, Prof Anthony Rodgers, PhD, Abdul Salam, PhD, Vanessa Selak, PhD, Sandrine Stepien, MSc, Prof Simon Thom, MD, Ruth Webster, PhD, Tracey Lea-Laba, PhD The Lancet Global Health Volume 7, Issue 10, Pages e1359-e1366 (October 2019) DOI: /S X(19) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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Figure 1 Structure of the discrete-time simulation model, depicting different health states that individuals could be in at each annual cycle The Lancet Global Health 2019 7, e1359-e1366DOI: ( /S X(19) ) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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Figure 2 Incremental cost-effectiveness plane of 1000 bootstrap replications assessing the additional cost per disability-adjusted life-year (DALY) averted, comparing the use of the triple pill versus usual care The Lancet Global Health 2019 7, e1359-e1366DOI: ( /S X(19) ) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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Figure 3 Cost-effectiveness acceptability curve
The probability that the triple-pill strategy is cost-effective compared with usual care for individuals with mild-to-moderate hypertension at different willingness to pay thresholds for each disability-adjusted life-year (DALY) averted. The Lancet Global Health 2019 7, e1359-e1366DOI: ( /S X(19) ) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions
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