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Efficacy of prostaglandin E1 in the treatment of lower extremity ischemic ulcers secondary to peripheral vascular occlusive disease  James J. Schuler,

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Presentation on theme: "Efficacy of prostaglandin E1 in the treatment of lower extremity ischemic ulcers secondary to peripheral vascular occlusive disease  James J. Schuler,"— Presentation transcript:

1 Efficacy of prostaglandin E1 in the treatment of lower extremity ischemic ulcers secondary to peripheral vascular occlusive disease  James J. Schuler, M.D., D.Preston Flanigan, M.D., James W. Holcroft, M.D., Joseph J. Ursprung, Ph.D., J.Scott Mohrland, Ph.D., Judy Pyke, M.S.  Journal of Vascular Surgery  Volume 1, Issue 1, Pages (January 1984) DOI: / (84) Copyright © 1984 Mosby, Inc. Terms and Conditions

2 Fig. 1 Final result of PGE1 vs. placebo treatment showing percent of ulcers that healed completely, were reduced by 20% or more in surface area, remained unchanged or increased by 20% or more, developed during the course of treatment, and had inadequate follow-up. The differences between treated group and placebo were not significant. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Mosby, Inc. Terms and Conditions

3 Fig. 2 Percent of patients in two groups with at least one ulcer completely healed during course of study. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Mosby, Inc. Terms and Conditions

4 Fig. 3 Percent of patient in two groups who had a 20% or greater reduction in total ulcer surface area as compared with those that remained unchanged or increased by 20% or more following one infusion of PGE1 or placebo. Differences between two groups were not significant. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Mosby, Inc. Terms and Conditions

5 Fig. 4 Percent of patients in two groups who had a 20% greater reduction in total ulcer surface area as compared with those that remained unchanged or increased or increased by 20% or more at final follow-up visit 2 months after last infusion. Differences between two groups were not significant. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Mosby, Inc. Terms and Conditions

6 Fig. 5 Average of patients' subjective evaluation of degree of rest pain graded on a scale of 0 to 7 prior to beginning of treatment and at time of final follow-up 2 months after last infusion. These differences were not significant. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Mosby, Inc. Terms and Conditions

7 Fig. 6 Average of analgesic medication use required for relief of rest pain graded on a scale of 0 to 5 prior to beginning of treatment and at time of final follow-up 2 months after last infusion. These differences were not significant. Journal of Vascular Surgery 1984 1, DOI: ( / (84) ) Copyright © 1984 Mosby, Inc. Terms and Conditions

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