1. Key functions of eosinophils (Eo) in resolution of inflammation in asthma.
Key functions of eosinophils (Eo) in resolution of inflammation in asthma. Eosinophils secrete a wide array of cytotoxic and pro-inflammatory mediators. In addition, eosinophils may contribute to resolution of inflammation in asthma by producing pro-resolving lipid mediators (PD1 and RvE3), by secreting interleukin (IL)-10 and by promoting alternative macrophage activation in an IL-4 and IL-13 dependent manner. PMN: polymorphonuclear leukocyte; PD1: protectin D1; RvE3: resolvin E3; EPA: eicosapentaenoic acid; DHA: docosahexaenoic acid; LOX: lipoxygenase.
Cindy Barnig, and Bruce D. Levy Eur Respir Rev 2015;24:
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