1. Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis
The rate of atrophied T2 lesion volume was higher in patients with progressive multiple sclerosis (MS) than in patients with other MS subtypes or in healthy control subjects (111.1 mm3 vs 71.3 mm3 vs 5.4 mm3, respectively; P < .001).
Patients with disease progression had increased atrophied T2 lesion volume (93 mm3 vs 59 mm3; P < .001) and percentage brain volume change (−0.9% vs −0.7%; P = .042) when compared with patients without disease progression.
Atrophied T2 lesion volume was the only MRI marker associated with conversion to secondary progressive MS (82 mm3 vs 56 mm3; P = .002).
In a patient that converted to secondary progressive MS, the top row shows the baseline ventricle and lesion volumes. The bottom row obtained at follow-up shows a magenta area of cerebrospinal fluid that was brain tissue at baseline (atrophied T2 lesion volume).
Genovese AV et al. Published Online: September 24,