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Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions  H.F. Galley, N.E.

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Presentation on theme: "Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions  H.F. Galley, N.E."— Presentation transcript:

1 Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions  H.F. Galley, N.E. El Sakka, N.R. Webster, D.A. Lowes, B.H. Cuthbertson  British Journal of Anaesthesia  Volume 100, Issue 6, Pages (June 2008) DOI: /bja/aen079 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 The effect of exposure of isolated human neutrophils to 100 ng ml−1 activated protein C (APC) on migration towards 1 nM interleukin-8 or 1 μM FMLP. Box and whisker plots are median, interquartile, and full range (n=10). British Journal of Anaesthesia  , DOI: ( /bja/aen079) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 The effect of exposure on isolated human neutrophils to 2 μg ml−1 lipopolysaccharide (LPS) and 0–200 ng ml−1 activated protein C (APC) on (a) respiratory burst (NS) and (b) apoptosis (NS). Box and whisker plots are median, interquartile, and full range (n=10). British Journal of Anaesthesia  , DOI: ( /bja/aen079) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 The effect of exposure on isolated human neutrophils to 2 μg ml−1 lipopolysaccharide (LPS) plus 0, 2, 20, or 200 ng ml−1 activated protein C (APC) on interleukin-6 (P=0.04) expression. In order to show individual trends, data are shown as a percentage of each IL-6 concentration in the absence of APC (n=10). Freidman analysis of variance P=0.04. British Journal of Anaesthesia  , DOI: ( /bja/aen079) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

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