1. Systematic review of methodology used in clinical studies evaluating the benefits of proton beam therapy 
Mercy Ofuya, Lucy McParland, Louise Murray, Sarah Brown, David Sebag-Montefiore, Emma Hall 
Clinical and Translational Radiation Oncology 
Volume 19, Pages (November 2019)
DOI: /j.ctro
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2. Fig. 1
Flowchart of search strategy in accordance with PRISMA statement. Abbreviations: PBT Proton beam therapy; PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Clinical and Translational Radiation Oncology  , 17-26DOI: ( /j.ctro )
Copyright © 2019 The Author(s) Terms and Conditions

3. Fig. 2
Distribution of prospective and retrospective studies by year of publication (n = 219).
Clinical and Translational Radiation Oncology  , 17-26DOI: ( /j.ctro )
Copyright © 2019 The Author(s) Terms and Conditions

4. Fig. 3 Distribution of study designs used in included studies.
Clinical and Translational Radiation Oncology  , 17-26DOI: ( /j.ctro )
Copyright © 2019 The Author(s) Terms and Conditions

5. Fig. 4
Distribution of disease sites in adult and paediatric patients (n = 188). Abbreviation: CNS = Central nervous system.
Clinical and Translational Radiation Oncology  , 17-26DOI: ( /j.ctro )
Copyright © 2019 The Author(s) Terms and Conditions

6. Fig. 5
Distribution of phase II and III trials by disease site treated by PBT (n = 24). Abbreviation: CNS = Central nervous system.
Clinical and Translational Radiation Oncology  , 17-26DOI: ( /j.ctro )
Copyright © 2019 The Author(s) Terms and Conditions

7. Fig. 6
Distribution of geographical location of PBT treatment centre (n = 219). Abbreviation: PBT = Proton beam therapy.
Clinical and Translational Radiation Oncology  , 17-26DOI: ( /j.ctro )
Copyright © 2019 The Author(s) Terms and Conditions