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Pascal Chanez, MDa, Antonio M

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Presentation on theme: "Pascal Chanez, MDa, Antonio M"— Presentation transcript:

1 Involvement of endothelin in mononuclear phagocyte inflammation in asthma 
Pascal Chanez, MDa, Antonio M. Vignola, MDa, b, Bernard Albat, MDc, David R. Springall, PhDd, Julia M. Polak, PhDd, Philippe Godard, MDa, Jean Bousquet, MDa  Journal of Allergy and Clinical Immunology  Volume 98, Issue 2, Pages (August 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 FIG. 1 Expression of endothelin on monocytes and AMs, assessed by the APAAP method (statistical analysis by Mann-Whitney U test). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 FIG. 2 Spontaneous and LPS-induced release of endothelin from AMs (statistical analysis by Wilcoxon W test). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 FIG. 3 Endothelin levels in cell supernatants (SUP) and cell lysates (CELL) from AMs recovered from control subjects (▩) and patients with asthma (■). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 FIG. 4 Spontaneous and endothelin-induced release of fibronectin by AMs (between-group statistical analysis, Mann-Whitney U test; within-group statistical analysis, Wilcoxon W test). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 FIG. 5 Dose-response release of fibronectin by AMs stimulated by endothelin (n = 8). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

7 FIG. 6 Time-response release of fibronectin by AMs stimulated by endothelin (n = 3). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

8 FIG. 7 Spontaneous and endothelin-induced release of TNF-α by AMs (within-group statistical analysis, Wilcoxon W test; between-group statistical analysis, Mann-Whitney U test). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions


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