1. (A–E) demonstrate a kidney biopsy from a patient with lupus nephritis (LN) class V. Representative micrographs: (A), an inflammatory infiltrate with T cells as demonstrated by a positive CD3 staining.
(A–E) demonstrate a kidney biopsy from a patient with lupus nephritis (LN) class V. Representative micrographs: (A), an inflammatory infiltrate with T cells as demonstrated by a positive CD3 staining. (B), demonstration of interferon (IFN)-λ staining, predominantly found in the inflammatory infiltrate shown in (A) but also present in the glomeruli. (C), the same infiltrate from a consecutive section, stained with irrelevant isotype control antibody. (D), another part of the biopsy from the same patient, showing an inflammatory infiltrate with T cells as demonstrated by positive CD3 staining. (E), demonstration of IFNλ staining in that infiltrate. Original magnifications: ×20. (F), predominant expression of IFNλ in a cellular crescent formation in the glomeruli (original magnifications: ×40) in a kidney biopsy from a patient with LN class IV.
Agneta Zickert et al. Lupus Sci Med 2016;3:e000170
©2016 by Lupus Foundation of America