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Fig. 1 TH17 cell differentiation was severely impaired in Cxxc1-deficient mice. TH17 cell differentiation was severely impaired in Cxxc1-deficient mice.

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Presentation on theme: "Fig. 1 TH17 cell differentiation was severely impaired in Cxxc1-deficient mice. TH17 cell differentiation was severely impaired in Cxxc1-deficient mice."— Presentation transcript:

1 Fig. 1 TH17 cell differentiation was severely impaired in Cxxc1-deficient mice.
TH17 cell differentiation was severely impaired in Cxxc1-deficient mice. (A and B) Naive CD4+ T cells (CD4+CD25-CD62LhiCD44lo) from dLckcreCxxc1fl/fl or WT mice were differentiated into TH17 cells with (A) IL-6 and TGF-β1 or (B) IL-1β, IL-6, and IL-23 for 96 hours and then restimulated for intracellular cytokine staining. One of five to seven experiments is shown. (C and D) Naive CD4+ T cells (CD4+CD25-CD62LhiCD44lo) from ERT2creCxxc1fl/fl mice were differentiated into TH17 cells with (C) IL-6 and TGF-β1 or (D) IL-1β, IL-6, and IL-23 for 96 hours in the presence or absence of 4-OHT (4-Hydroxytamoxifen) and then restimulated for intracellular cytokine staining. One of five experiments is shown. (E and F) Naive CD4+ T cells from RORγtcreCxxc1fl/fl or WT mice were differentiated into TH17 cells with (E) IL-6 and TGF-β1 or (F) IL-1β, IL-6, and IL-23 for 96 hours and then restimulated for intracellular cytokine staining. One of seven experiments is shown. (G) Intracellular staining of IL-17A in lipoprotein lipase (LPL) CD4+ T cells in the small intestines of RORγtcreCxxc1fl/fl and WT mice. One of four experiments is shown. Error bars show the means ± SD. **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ using the Student’s t test. Feng Lin et al. Sci Adv 2019;5:eaax1608 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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