1. The Role of the Toxicologist
Toxicology
April 27, 2015
Sanders

2. Challenges Facing the Toxicologist
Toxicologists must determine toxins in body parts without any idea as to what type to look for.
Any given substance has to be given an individual test.
December 18, 2019
Toxicology

3. Determination
Forensic toxicologists must develop analytical tests to determine toxins.
Detect
Isolate
Identify
December 18, 2019
Toxicology

4. Testing Materials Tests must be run on biological material.
Biological fluids
Tissues
Organs
December 18, 2019
Toxicology

5. Screening Tests
A screening test gives quick insight into the probability that a sample contains a pharmaceutical substance
Legal
Illegal
December 18, 2019
Toxicology

6. Results
Positive results arising from a screening test are provisional then must be verified with a confirmation.
December 18, 2019
Toxicology

7. Positive Results The widely used screening tests are
Thin-layer chromatography
Technique used to separate non-volatile mixtures.
Gas chromatography
A test of analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition.
Immunoassay
A test for an antigen that can detect drugs in blood or urine.
Thin-layer chromatography (TLC) is a chromatography technique used to separate non-volatile mixtures.[1] Thin-layer chromatography is performed on a sheet of glass, plastic, or aluminium foil, which is coated with a thin layer of adsorbent material, usually silica gel, aluminium oxide, or cellulose. This layer of adsorbent is known as the stationary phase.
Gas chromatography (GC), is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture (the relative amounts of such components can also be determined). In some situations, GC may help in identifying a compound. In preparative chromatography, GC can be used to prepare pure compounds from a mixture
December 18, 2019
Toxicology

8. Confirmation Test Accepted tests for confirmation test of choice
Gas chromatography
Mass spectrometer
December 18, 2019
Toxicology

9. December 18, 2019
Toxicology

10. Confirmation
Once a drug is extracted and identified, a toxicologist may be required to judge the drug’s effect on an individual's natural performance or physical state.
December 18, 2019
Toxicology