1. Identification of bacterial species producing the anti-Candida molecules.
Identification of bacterial species producing the anti-Candida molecules. (A) Both Roseburia intestinalis and R. faecis secreted molecules exert antifungal activity. C. albicans cells were grown in SC medium with 8% GM or control medium, and OD595 readings were taken after 24 h of incubation at 30°C under agitation. Results represent growth inhibition (percent) after 24 h of treatment of at least three replicates. (B and C) Both Bacteroides ovatus strain 5MM (B) and strain S1D6FAA (C) reduced C. albicans hypha elongation. A total of 100 cells with three hypha length ranges (1 to 20, 21 to 40, and >40), measured in arbitrary units, were counted. Results are presented as the number of cells with a hypha length in the corresponding range.
Carlos García et al. mSphere 2017; doi: /mSphere