1. CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX 1 ITMO Cancer Cancer organisation in France CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX AVIESAN: National Alliance for life and health sciences INCa: National Cancer Institute

2. CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX Overview of Cancer research in France 800 research teams- 6000 researchers, MDs, Technicians and administrative staff 85 universities, 26 medical schools- 10 Institutions of which Inserm-CNRS … One single desk: AVIESAN Cancer National Cancer Institute – INCa: project funding A common strategy and a national cancer plan (2009-2014), dedicated budget : 2,5 billion euros including 500 millions for research 2

3. CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX Accelerating translation of innovation to patients Research InfrastructuresTools to improve research Comprehensive Cancer research centres – 8 SIRIC Early phase clinical trial centres - 16 CLIP 2 Molecular Genetics Centres Clinical trial Registry Clinical research Cohorts Data processing centres Cooperative groups Clinical-biological Databases 3

4. CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX 833 Aviesan Cancer teams 4 10-30 Teams 30-80 teams 80-350 teams 1-10 teams 336 53 5 8 2 6 1 75 61 2 7 38 49 46 3 20 1 16 1 1 1 2 10 3 3 21 25 212 50 57 2 13 2 Paris area

5. CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX 10 actions for the next 5 years 5 Genomics and personalized medicine Medication, molecular pharmacology and biomarkers Metabolism, infection, inflammation, immunology and cancer Human and social sciences and epidemiology Epidemiology, epigenetics and environment 1 2 3 4 5

6. CEACHRUCNRSCPUINRAINRIAINSERMINSTITUT PASTEURIRD ARIISEFSINERISINSTITUT CURIEINSTITUT MINES-TELECOMUNICANCERIRBAIRSNCIRADFONDATION MERIEUX 6 System Biology Physics/mathematics and cancer interfaces: Fundamental aspects and transfer toward clinical application Clinical research Training and technology transfer Society/patient information 6 7 8 9 10