1. Performance, safety, garantee of results
Isagro SpA – Product Development

2. FORMULATION
DOMARK is formulated as an emulsifiable concentrate (EC), that is a liquid formulation forming an emulsion after dilution in water
Solvent based formulation where the active ingredient TETRACONAZOLE is dissolted in organic solvents, nonilphenols free, favouring its penetration and biological activity
Excellent stability when stored at either high or low temperatures

3. TETRACONAZOLE
a broad spectrum systemic triazole fungicide discovered by
Tetraconazole is ISAGRO’s proprietary molecule
At present more than 140 registrations have been obtained in 60 countries and others are pending

4. TECHNICAL FEATURES Chemical class: triazoles
Common name: tetraconazole
Chemical class: triazoles
Mechanism of action: IBS – Sterol Biosynthesis Inhibitor
Mode of action: systemic fungicide

5. TETRACONAZOLE DISTRIBUTION
Tetraconazole, among all the triazoles, is the compound with the best balance between hydrosolubility and liposolubility and thanks to this property it ensures:
Swift penetration and traslocation within the plant
Translaminar movement
Systemicity through the upward lymphatic stream
Homogeneous distribution inside the plant without local
accumulation
Preventive and curative activity

6. TETRACONAZOLE DISTRIBUTION
Translocation through
the sap
Hydrosolubility
Liposolubility
Vapour tension
Diffusion through the lipids and the cuticolar waxes
Redistribution on and inside
the plant

7. TETRACONAZOLE DISTRIBUTION
Excellent balance between hydrosolubility and liposolubility

8. RADIO LABELED MOLECULE IN SUGAR BEET LEAF
DISTRIBUTION IN THE PLANT
RADIO LABELED MOLECULE IN SUGAR BEET LEAF
3 days
7 days
2 hours
Treated area
14 days

9. RADIO LABELED MOLECULE IN GRAPE LEAF
DISTRIBUTION IN THE PLANT
RADIO LABELED MOLECULE IN GRAPE LEAF
2 hours
3 days
Treated area
7 days
10 days

10. SELECTIVITY
Some important biochemical processes, such as gibberellins and phytosterols
synthesis, are regulated by cytochrome - P450 – based enzymes; due to its
particular molecular structure tetraconazole does not interfere with these
processes but only with the ergosterol biosynthesis of the fungus
No phytotoxic effects on the treated plant have ever been seen

11. TETRACONAZOLE PREVENTIVE ACTIVITY
Mechanism of Action
Germ tube
growth
Formation of
appressorium
and penetration
Beginning of
mycelial growth
and colonization
Colonization of tissues not
allowed with TETRACONAZOLE X
TETRACONAZOLE
botrytis_KBR.ppt

12. TETRACONAZOLE CURATIVE ACTIVITY
Mechanism of Action
Beginning of
mycelial growth
and colonization
Damage already set (colonization of tissues
resulting in cell death and necrosis) but
stopped with TETRACONAZOLE application
Tetraconazole
Tetraconazole
Tetraconazole
Tetraconazole
Tetraconazole
Tetraconazole
botrytis_KBR.ppt

13. MAIN USES OF TETRACONAZOLE
Crops and diseases
Cercospora,
Rust
P. mildew,
Ramularia
Rusts, Septoria, P. mildew
Cercospora
Bipolaris
Rhizoctnia
Pyricularia
Bipolaris
P. Mildew, scab
P. mildew
P. mildew
alternaria
P. mildew
P. mildew
Rust,
Cercospora,
Septoria
Sclerotinia,
Alternaria
Rust

14. DOMARK is the solution to farmers and distributor’s needs as it provides:
Effective control of several pathogen affecting different crops
Costant performance
Selectivity towards the crop
Inventory optimization

15. ADVANTAGES OF TETRACONAZOLE
Broad spectrum of action
Wide window of application
Excellent selectivity
Great systemicity granting a uniform protection of the crop
Good activity as protectant and curative fungicide
Effective and safe at either high or low temperatures
Low usage rate
Versatility/compatibility with other products
Environmentally friendly (good eco-tox profile)

16. Thank you for your attention