1. MNW leerlijn Bioinformatics Bioinformatics & Systems Biology Faculty of Sciences & Faculty of Earth and Life Sciences Jaap Heringa – 12 sep 2011

2. Teachers (Bioinformatics & Systems Biology) dr. Sanne Abeln (UD Bioinformatics) dr. Anton Feenstra (UD Bioinformatics) prof. dr. Jaap Heringa (Prof. Bioinformatics) dr. Frank Bruggeman (UD Systems Biology) dr. Douwe Molenaar (UHD Systems Bioinformatics) prof. dr. Bas Teusink (Prof. Systems Bioinformatics) - the people

3. From anatomy to dynamics to systems biology and bioinformatics time  Statics, anatomy, architecture  Dynamics, mechanics  Informatics (Cybernetics – Wiener, 1948) (Cybernetics has been defined as the science of control in machines and animals, and hence it applies to technological, animal and environmental systems)  Genomics, bioinformatics, systems biology

4. Bioinformatics & Systems Biology as interdisciplinary sciences Mathematics Statistics Computer Science Informatics Biology Molecular biology Medicine Chemistry Physics Bioinformatics & Systems Biology

5. Bioinformatics & Systems Biology The big bang…

6. The Human Genome Project

7. From DNA… OH BRAD,THEY SAY THERE’S DNA IN MY BODY! WHO CARES, DARLING,...WHO CARES........acctc ctgtgcaag acatgaaaca cccgatttac nctgtggttc cccagatgg gtcctgtccc aggtgcacct gcaggagtcg gcccaggac tggggaagcc tccagagctc aaaaccccac tggtgacac aactcacaca tgcccacggt gcccagagcc aaatcttgt gacacacctc ccccgtgccc acggtgccca agcccaaat cttgtgacac acctccccca tgcccacggt cccagagcc caaatcttgt gacacacctc ccccgtgccc cggtgccca gcacctgaac tcttgggagg accgtcagtc tcctcttcc ccccaaaacc caaggatacc cttatgattt ccggacccc tgaggtcacg tgcgtggtgg tggacgtgag cacgaagac cctnnngtcc agttcaagtg gtacgtggac gcgtggagg tgcataatgc caagacaaag ctgcgggagg gcagtacaa cagcacgttc cgtgtggtca gcgtcctcac gtcctgcac caggactggc tgaacggcaa ggagtacaag gcaaggtct ccaacaaagc aaccaagtca gcctgacctg ctggtcaaa ggcttctacc ccagcgacat cgccgtggag gggagagca atgggcagcc ggagaacaac tacaacacca gcctcccat gctggactcc gacggctcct tcttcctcta agcaagctc accgtggaca agagcaggtg gcagcagggg acatcttct catgctccgt gatgcatgag gctctgcaca ccgctacac gcagaagagc ctctc.....

8. It’s the network stupid!

9. next generation sequencing (baseclear) mammaprint (agendia) Research in Bioinformatics model + algoritme clinical trials (chdr)

10. Theme 1: Sequence based research http://zeus.few.vu.nl/programs/shmrwww/example/

11. Reversible oligomerization Irreversible fiber formation Theme 2: Structure based research

12. Theme 3: Function based research the network level

13. Een revolutie in de biologie…

14. Bioinformatics & Systems Biology data knowledge hoe gaan we die data organiseren en gebruiken? Hoe gaan we om met de complexiteit van biologische systemen?

15. Systeembiologie is de biologie van de toekomst…

16. Bioinformatics and Systems Biology Bioinformatica probeert biologische componenten te interpreteren (labelen) voorspel structuur of functie van een eiwit reconstueer netwerk topologie er is meestal geen tijdscomponent Systeembiologie probeert de processen door de tijd te begrijpen meestal op netwerkniveau

17. Contact Master Bioinformatics Jaap Heringa j.heringa@vu.nl Sanne Abeln s.abeln@vu.nl Anton Feenstra k.a.feenstra@vu.nl Bas Teusink b.teusink@vu.nl Douwe Molenaar d.molenaar@vu.nl

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