3. ANTHRAX BACTERIUM

13. Protective antigen (PA) Edema factor (EF) Lethal factor (LF) PA+LF combine to produce lethal activity EF+PA produce edema EF+LF is inactive PA+LF+EF produces edema and necrosis and is lethal

14. Lethal factor cuts enzymes in two -- the enzymes that are responsible for transmitting signals within the cells in the mitogen-activated protein kinase (MAPK) pathway, which helps control cell growth, embryonic development and the way oocytes (eggs) mature A-B enzymatic-binding structure of bacterial exotoxins with PA-key, EF/LF-lock/active site. The virulence of Bacillus anthracis is attributable to three bacterial components: 1. Capsular material composed of poly-D-glutamate 2. EF component of exotoxin 3. LF component of exotoxin

23. To be continued… Thank you for your attentiveness