Presentation is loading. Please wait.

Presentation is loading. Please wait.

What causes cystic fibrosis?

Published byTyler Burton Modified over 11 years ago

Similar presentations

Presentation on theme: "What causes cystic fibrosis?"— Presentation transcript:

1 What causes cystic fibrosis?
A mutation in the cystic fibrosis transmembrane regulatory protein

2 What does the CFTR protein do?
It helps control the viscosity (or stickiness) of mucus that lines the epithelial cells of the airways, digestive and reproductive systems mucus cilia epithelial cell If the mucus in airways is… too sticky: the cilia cannot beat and remove the mucus, which then clogs up airways too runny: the mucus can flood the airways

3 When there is excess water in the mucus
Water is drawn out of the mucus and it thickens Cl- Na+ H2O mucus 2 apical membrane 5 CFTR channel closed Na+ channel open H2O pump 1 basal membrane 4 3 tissue fluid H2O Cl- Na+

4 When there is too little water in the mucus
Water is drawn out of the mucus and it becomes less sticky Cl- Na+ Na+ mucus 3 2 4 apical membrane Na+ channel closed CFTR channel open H2O The CFTR somehow blocks the sodium channels Cl- 1 H2O basal membrane 5 pump tissue fluid H2O Na+

5 With cystic fibrosis X The mucus becomes very thick and sticky mucus
Cl- Na+ H2O mucus 1 2 3 X apical membrane CFTR non- functional The CFTR protein cannot block the sodium channels so they are always open Water drawn out by osmosis Na+ channel open H2O basal membrane H2O tissue fluid Cl-

6 How cystic fibrosis affects the lungs
Sticky mucus builds up in the airways, reducing flow of air into alveoli. Lungs gradually fill up with mucus, making them less effective for gas exchange. Symptoms: Severe coughing - to remove excess mucus. Breathlessness - shortage of oxygen increases tiredness and lack of energy Infections - as bacteria are trapped in mucus

7 How does cystic fibrosis affect the reproductive systems?
Men Women Sperm duct is blocked and prevents movement of sperm During the menstrual cycle the levels of mucus vary. Can lack the sperm ducts Women with CF have thick levels of mucus which can block the cervix so sperm cannot reach them.

8 How cystic fibrosis affects the digestive system:
Thick, sticky mucus blocks the pancreatic duct preventing enzymes from reaching the duodenum. Food is not digested and absorbed sufferers fail to put on body mass and suffer malnutrition. Trapped digestive enzymes damage the pancreatic cells affecting cells producing insulin resulting in diabetes.

Download ppt "What causes cystic fibrosis?"

Similar presentations

1. 2. 3. 4. Thick mucus in airways and lungs and breathing problems Chronic lung infections Digestive problems that lead to poor growth Increased salty.

Thick mucus in airways and lungs and breathing problems Chronic lung infections Digestive problems that lead to poor growth Increased salty.
Nutrient Transport. Balance Between Absorptive and Secretory Processes in Gut Figures for adult human Secretion 1500 ml saliva 2000 ml gastric secretion.

Nutrient Transport. Balance Between Absorptive and Secretory Processes in Gut Figures for adult human Secretion 1500 ml saliva 2000 ml gastric secretion.
Cystic Fibrosis ROSA RODRIGUEZ. What is it?  Cystic fibrosis is a hereditary disease that affects the cystic fibrosis transmembrane conductance regulator.

Cystic Fibrosis ROSA RODRIGUEZ. What is it?  Cystic fibrosis is a hereditary disease that affects the cystic fibrosis transmembrane conductance regulator.
Cystic fibrosis. Cystic fibrosis (CF) is an autosomal recessive genetic disorder that affects most critically the lungs, and also the pancreas, liver,

Cystic fibrosis. Cystic fibrosis (CF) is an autosomal recessive genetic disorder that affects most critically the lungs, and also the pancreas, liver,
CYSTIC FIBROSIS FANOURAKI MARIA 27137 CHARALAMPIDOU ALEXANDRA 27138.

CYSTIC FIBROSIS FANOURAKI MARIA CHARALAMPIDOU ALEXANDRA
Genes and Health Think about GCSE – What do you know about Genes/Genetics? What do these words make you think of? What affects do our Genes have on health?

Genes and Health Think about GCSE – What do you know about Genes/Genetics? What do these words make you think of? What affects do our Genes have on health?
Three main types of lung disease Airway diseases -- These diseases affect the tubes (airways) that carry oxygen and other gases into and out of the lungs.

Three main types of lung disease Airway diseases -- These diseases affect the tubes (airways) that carry oxygen and other gases into and out of the lungs.
Year 10 – Genetics and Biotechnology (Biology) Genetic disorders.

Year 10 – Genetics and Biotechnology (Biology) Genetic disorders.
Membranes A cell’s plasma membrane defines a cell and separates it from its environment. Yet at the same time, it must allow for interaction between the.

Membranes A cell’s plasma membrane defines a cell and separates it from its environment. Yet at the same time, it must allow for interaction between the.
Cystic Fibrosis and The Effects on the Pancreas By Jon Obert.

Cystic Fibrosis and The Effects on the Pancreas By Jon Obert.
 The first known definition of Cystic Fibrosis was written in 1938 by Dr. Dorothy Anderson, a pathologist in the New York Babies Hospital.  In the 17.

 The first known definition of Cystic Fibrosis was written in 1938 by Dr. Dorothy Anderson, a pathologist in the New York Babies Hospital.  In the 17.
Cystic Fibrosis Bronte Short. What Cause Cystic Fibrosis? Cystic fibrosis, is an autosomal recessive hereditary disease that mostly affects the lungs,

Cystic Fibrosis Bronte Short. What Cause Cystic Fibrosis? Cystic fibrosis, is an autosomal recessive hereditary disease that mostly affects the lungs,
BY ELIZABETH LITTLE AND LEAH RAYGO Cystic Fibrosis: The Crisis in Ireland.

BY ELIZABETH LITTLE AND LEAH RAYGO Cystic Fibrosis: The Crisis in Ireland.
IIt is a genetic disease that is passed down through families that causes a thick, sticky mucus to build up in the lungs, digestive tract, and other.

IIt is a genetic disease that is passed down through families that causes a thick, sticky mucus to build up in the lungs, digestive tract, and other.
Respiratory system. The primary function of the respiratory system is the supply of oxygen to the blood and the removal of carbon dioxide.

Respiratory system. The primary function of the respiratory system is the supply of oxygen to the blood and the removal of carbon dioxide.
Chromosomal Mutations and Karyotypes Genetic Variation- differences in genetic material Caused by: segregation crossing over (during meiosis) recombination.

Chromosomal Mutations and Karyotypes Genetic Variation- differences in genetic material Caused by: segregation crossing over (during meiosis) recombination.
CAUSES OF CYSTIC FIBROSIS CF is caused by a mutation in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). This protein.

CAUSES OF CYSTIC FIBROSIS CF is caused by a mutation in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). This protein.
Sweat Test. A sweat test measures the amount of salt chemicals (sodium and chloride) in sweat. Sodium and chloride are part of your body’s electrolyte.

Sweat Test. A sweat test measures the amount of salt chemicals (sodium and chloride) in sweat. Sodium and chloride are part of your body’s electrolyte.
IB2.28.3 Genetic disorders © Oxford University Press 2011 Genetic disorders.

IB Genetic disorders © Oxford University Press 2011 Genetic disorders.
Things That Can Go Wrong With the Lungs and Respiratory System

Things That Can Go Wrong With the Lungs and Respiratory System

Similar presentations

Ads by Google