1. The Synthetic Bone Company™
Edward S. Ahn, Ph.D.
The Synthetic Bone Company™
Utilizing Nanotechnology to
Develop Medical Devices
Angstrom Medica, Inc A New Boston Street Woburn, MA

2. Angstrom Medica, Inc. - Proprietary and Confidential
Why Nanotechnology?
All interactions occur at an interface
Maximize interactions by maximizing interface
Increase surface area to volume ratio
Unique size dependent properties
Angstrom Medica, Inc. - Proprietary and Confidential

3. Nanotechnology and the Medical Device
510(k) or PMA?
Physician
Input
Product
Definition
Regulatory
Approval
Manufacturing
Sales
Does nanotechnology
solve a compelling
clinical need?
Can you make it?
FINANCING
Do the potential rewards out weigh risks?
Angstrom Medica, Inc. - Proprietary and Confidential

4. Angstrom Medica, Inc. - Proprietary and Confidential
Defining The Product
Compelling Clinical Need
What kind of product?
Incremental product improvement
Revolutionary procedure
Issues
Technology looking for a home
How do clinicians contextualize nanotechnology?
Are there more conventional alternatives?
Angstrom Medica, Inc. - Proprietary and Confidential

5. Angstrom’s Products 100 nm 100 nm Bone Screws Spinal Fusion Devices
Angstromplasty
Hip Fracture Prevention
100 nm
100 nm
Angstrom Medica, Inc. - Proprietary and Confidential

6. Angstrom Medica, Inc. - Proprietary and Confidential
FDA Approval
Same but different strategy
First nanomedical device approved by FDA
Nanocrystalline CaP bone void filler
Incremental product improvement
Should be 510(k)
Bone screws and spinal fusion devices
Revolutionary Procedure
May require clinical trials
Angstromplasty
Angstrom Medica, Inc. - Proprietary and Confidential

7. Angstrom Medica, Inc. - Proprietary and Confidential
Manufacturing
Nanotechnology = Expensive?
Infrastructure
Specialized talent
Multi-step processing
Limited outsourcing
Reproducibility and Reliability
Nanotechnology is stochastic
Angstrom Medica, Inc. - Proprietary and Confidential

8. Angstrom’s Manufacturing Process
Precipitation
Forging
Machining
100 nm
Angstrom Medica, Inc. - Proprietary and Confidential

9. Angstrom Medica, Inc. - Proprietary and Confidential
Financing
Grants
Angel Investors
Strategic Partners
Institutional Investors
Technical Risk
Marketing Risk
Execution Risk
Angstrom Medica, Inc. - Proprietary and Confidential

10. engineering small miracles™
Angstrom Medica, Inc A New Boston Street Woburn, MA