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Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL by Arian.

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Presentation on theme: "Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL by Arian."— Presentation transcript:

1 Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL by Arian van der Veer, Esmé Waanders, Rob Pieters, Marieke E. Willemse, Simon V. Van Reijmersdal, Lisa J. Russell, Christine J. Harrison, William E. Evans, Vincent H. J. van der Velden, Peter M. Hoogerbrugge, Frank Van Leeuwen, Gabriele Escherich, Martin A. Horstmann, Leila Mohammadi Khankahdani, Dimitris Rizopoulos, Hester A. De Groot-Kruseman, Edwin Sonneveld, Roland P. Kuiper, and Monique L. Den Boer Blood Volume 122(15):2622-2629 October 10, 2013 ©2013 by American Society of Hematology

2 CIR for the BCR-ABL1-like expression signature, IKZF1-deleted, and high CRLF2 mRNA expression in newly diagnosed children with BCR-ABL1–negative, MLL wild-type BCP-ALL. van der Veer A et al. Blood 2013;122:2622-2629 ©2013 by American Society of Hematology

3 CIR for IKZF1 status among subtypes of ALL. CIR with death as a competing event was calculated for the DCOG ALL-10 study cases with (A) high hyperdiploid ALL (>50 chromosomes) including 21 IKZF1-deleted and 87 wild-type cases; (B) ETV6-RUNX1–positive ALL in... van der Veer A et al. Blood 2013;122:2622-2629 ©2013 by American Society of Hematology

4 Frequency of BCR-ABL1-like, IKZF1-deleted, and CRLF2-high mRNA expression features among children with BCR-ABL1–negative, MLL wild-type BCP-ALL. van der Veer A et al. Blood 2013;122:2622-2629 ©2013 by American Society of Hematology

5 Interaction between BCR-ABL1-like and IKZF1 status for predicting relapse. van der Veer A et al. Blood 2013;122:2622-2629 ©2013 by American Society of Hematology

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