1. GEMSS: Grid-Enabled Medical Simulation Services Healthgrid Cluster Meeting Project Overview: Profile from CORDIS Consortium Project Goals / Objectives GEMSS System Design Medical Applications Clustering IST-2001-37153

2. GEMSS Project Profile (Cordis) Project Acronym: GEMSS Title: GRID-enabled Medical Simul. Services Subject Index : Policies; Legislation, Regulations;Information Processing, Information Systems; Electronics, Microelectronics Start Date: 2002-09-01End Date: 2005-02-28 Duration: 30 Ms Project Status:Accepted Project Cost:3.59 million € Funding: 2.63 million € Programme Type:5th FWP (Fifth Framework Programme) Programme Acronym :IST Subprogramme Area: Cross Programme Actions (CPA) – CPA9: Grid test beds, deployment and technologies Project Reference:IST-2001-37153 Contract Type:CSC (Cost-sharing contracts)

3. GEMSS Consortium NoPartnerRoleCountrySpecific Expertise 1NEC C C&C R.L. UK (Germany) 2MPI PGermany 3ISS PAustria 4USFD P STH S UK 5AEA PUK 6IT- P Innovation UK 7CRID PBelgium 8ASD AGermany 9IDAC AIreland 10IBMTP AAustria Simulation /Imaging SW Grid Software /solutions Bio-numeric modelling Medical Expertise Legal Aspects Legend: C – Co-ordinator P – Principal Contractor S – Subcontractor A – Associate Contractor

4. 1.Install an extendible, interoperable and collaborative testbed for GRID-enabled medical application services, 2.Demonstrate the medical significance of the GEMSS models, 3.Demonstrate the functionality of the GRID- infrastructure, 4.Open a business model for future commercial exploitation. The main goals of GEMSS are :

5. Simulation portal Medical simulation service Portal + networked compute resources Pre- & Post- processing User-site (SW installed) GRID SW GRID SW (interface) Applications SW GRID SW (service use) Internet or Intranet Internet or Intranet Could also be moved to the services portal Simulation Service System A general overview / possible scenario

6. GEMSS Project Objectives GEMSS will demonstrate that the Grid can be used to provide medical practitioners and researchers with access to advanced simulation and image processing services for improved pre-operative planning and near real-time surgical support. The GEMSS will build on top of existing Grid technologies, maintaining compliance with standards thereby ensuring future extensibility and interoperability, to provide support for authorisation, workflow, security, error detection and recovery. Test-bed to evaluate & validate the GEMSS environment, including its integration into the end-users working environments. GEMSS aims to anticipate privacy, security and other legal concerns by examining and incorporating into its Grid services the latest laws and EU regulations related to providing medical services over the Internet.

7. GEMSS System Design Generic GRID-services: build on existing GRID and WEB technologies like OGSA, Web services, Jini and Corba, service interaction models, protocols & interfaces, QoS (time critical services), security models compliant with European legal issues, fail-over and recovery from errors, workflow and service orchestration techniques for time-critical processes, medical GRID portals, PSEs, application servers. Collaborative tools: tele-support, tele-consulting. Medical service applications: Numerical modelling, based on existing software packages such as CFX and EASA, High Performance Computing (HPC) simulation, FE analysis, Advanced image processing.

8. Application Layer Collective Layer Resource Layer Fabric Layer Grid Architecture Applications, Portals, Environments Higher Services, APIs, Protocols APIs, Protocols, SDKs Computers, Networks, Devices

9. Application Layer Collective Layer Resource Layer Fabric Layer Grid Architecture Applications, Portals, Environments Higher Services, APIs, Protocols APIs, Protocols, SDKs Computers, Networks, Devices Globus toolkit

10. Application Layer Collective Layer Resource Layer Fabric Layer Grid Architecture Applications, Portals, Environments Higher Services, APIs, Protocols APIs, Protocols, SDKs Computers, Networks, Devices Condor

11. Application Layer Collective Layer Resource Layer Fabric Layer Grid Architecture Applications, Portals, Environments Higher Services, APIs, Protocols APIs, Protocols, SDKs Computers, Networks, Devices Legion

12. Application Layer Collective Layer Resource Layer Fabric Layer Grid Architecture Applications, Portals, Environments Higher Services, APIs, Protocols APIs, Protocols, SDKs Computers, Networks, Devices UNICORE

13. Application Layer Collective Layer Resource Layer Fabric Layer Grid Architecture Applications, Portals, Environments Higher Services, APIs, Protocols APIs, Protocols, SDKs Computers, Networks, Devices Condor UNICORE Which one to use? Legion Globus toolkit

14. GEMSS: Medical Applications Test-bed Applications (1) Maxillo-facial surgery simulation. (2) Neuro-surgery support. (3) Radio-surgery simulation. (4) Inhaled drug-delivery simulation. (5) Cardio-vascular system simulation. (6) Advanced image reconstruction. Phase I: Halo positioning Maxillo-facial Surgery Simulation During maxillo-facial surgery a steel device is tightly fixed to the head by special screws. These screws deform the skull which becomes clearly visible as a result of a parallel finite element analysis. The goal is to provide a virtual planning space for the optimisation the fixation and distraction procedures. Partners: NEC MPI Phase II: Distraction Procedure

15. Test-bed Applications (1) Maxillo-facial surgery simulation. (2) Neuro-surgery support. (3) Radio-surgery simulation. (4) Inhaled drug-delivery simulation. (5) Cardio-vascular system simulation. (6) Advanced image reconstruction. Neuro Surgery Support Prediction of the brain shift during neurosurgery is important to provide co-ordinates for the surgical navigation. In GEMSS a robust and precise approach based on non- linear image registration will be implemented in a Grid environment. Partner(s): MPI GEMSS: Medical Applications

16. Test-bed Applications (1) Maxillo-facial surgery simulation. (2) Neuro-surgery support. (3) Radio-surgery simulation. (4) Inhaled drug-delivery simulation. (5) Cardio-vascular system simulation. (6) Advanced image reconstruction. Radio-surgery simulation Revised treatment plan simulated - different beam weighting and orientation RAPT simulation now shows better coverage - differs from conventional treatment analysis New treatment more likely to be successful. Partner(s): IT-Innovation, USFD GEMSS: Medical Applications

17. Test-bed Applications (1) Maxillo-facial surgery simulation. (2) Neuro-surgery support. (3) Radio-surgery simulation. (4) Inhaled drug-delivery simulation. (5) Cardio-vascular system simulation. (6) Advanced image reconstruction. Inhaled Drug-Delivery Simulation Take-up of the Cophit project – A combination of computational fluid dynamics and 1-dimensional models to optimise delivery of inhaled drugs to the lung. Partner(s): USFD, AEA, ASD GEMSS: Medical Applications

18. Test-bed Applications (1) Maxillo-facial surgery simulation. (2) Neuro-surgery support. (3) Radio-surgery simulation. (4) Inhaled drug-delivery simulation. (5) Cardio-vascular system simulation. (6) Advanced image reconstruction. Cardio-vascular System Simulation A compartmental approach and coupled structural mechanics and fluid dynamics will be applied to simulate the entire cardio-vascular system. Partner(s): USFD, AEA, ASD, IDAC GEMSS: Medical Applications Heart-valve example kindly provided by the BLOODSIM project.

19. Advanced Image Reconstruction Entropy-based parallel Projection Image Reconstruction for SPECT. The medical image reconstruction system is based on a service oriented architecture to provide clients with advanced fully 3D image reconstruction services running transparently on remote parallel computers. Partner(s): ISS, IBMTP Test-bed Applications (1) Maxillo-facial surgery simulation. (2) Neuro-surgery support. (3) Radio-surgery simulation. (4) Inhaled drug-delivery simulation. (5) Cardio-vascular system simulation. (6) Advanced image reconstruction. GEMSS: Medical Applications Hospital A Internet Agent Reconstruction Service... GRID... Hospital Z

20. Healthgrid Cluster Activities GEMSS contributions: Participation in the GGF. Participation in GridStart. Establish contact with related projects to identify common interests and synergies. Consolidation of technical developments. Identification of possible tool sharing. Interoperability and standardisation efforts. Common dissemination in health-related events.

21. Suggestions for Clustering CROSSGRID As the first application, a Grid-based prototype system for pre- treatment planning in vascular interventional and surgical procedures will be developed through real-time interactive simulation of vascular structure and flow. The system consists of a distributed real- time simulation environment, in which a user interacts in Virtual Reality (VR). A 3D model of the arteries, derived using medical imaging techniques, will serve as input to a real-time simulation environment for blood flow calculations. The user will be allowed to change the structure of the arteries, thus mimicking a surgical procedure and the effects of this adaptation will be analysed in real time while the results are presented to the user in a virtual environment.

22. Suggestions for Clustering CROSSGRID + GEMSS common interests: Simulation/visualisation, Medical LBA (Lattice Boltzmann for scan data)

23. Suggestions for Clustering EUROGRID (Bio/Meteo/CAE-GRID) The objectives of the EUROGRID project are: To establish a European GRID network of leading High Performance Computing centres from different European countries. To operate and support the EUROGRID software infrastructure. The EUROGRID software will use the existing Internet network and will offer seamless and secure access for the EUROGRID users. To develop important GRID software components and to integrate them into EUROGRID (fast file transfer, resource broker, interface for coupled applications and interactive access). To demonstrate distributed simulation codes from different application areas (Biomolecular simulations, Weather prediction, Coupled CAE simulations, Structural analysis, Real-time data processing). To contribute to the international GRID development and to liase with the leading international GRID projects. To productise the EUROGRID software components. After project end the EUROGRID software will be available as supported product.

24. Suggestions for Clustering EUROGRID + GEMSS common interests: UNICORE Bio-GRID HPC GRID

25. GEMSS: Contact & Info Contact:fingberg@ccrl-nece.defingberg@ccrl-nece.de Dr. Jochen Fingberg C&C Research Laboratories NEC Europe Ltd. Tel. +49 2241 92520 Project site:http://www.gemss.dehttp://www.gemss.de Cordis:http://dbs.cordis.lu