1. Cytidine analogue ALL, AML
cytarabine (araC)
Cytidine analogue
ALL, AML

2. Guanine analogue AML Watch myelosuppression and GI perforation
thioguanine
Guanine analogue
AML
Watch myelosuppression and GI perforation

3. cyclophosphamide Alkylating agent (binds DNA)
Autoimmune diseases, leukemias/lymphomas
Beware hemorrhagic cystitis

4. vinblastine Prevents microtubule polymerization
Metastatic testicular cancer and lymphoma
Marrow suppression is dose-limiting

5. Alkylating agent Hodgkin’s disease
dacarbazine
Alkylating agent
Hodgkin’s disease

6. irinotecan Topoisomerase I inhibitor Colorectal cancer
Beware life-threatening diarrhea

7. Alkylating agent Hodgkin’s disease
procarbazine
Alkylating agent
Hodgkin’s disease

8. Thymidylate synthase inhibitor Breast, GI, and skin cancer (topical)
5-FluoroUracil
Thymidylate synthase inhibitor
Breast, GI, and skin cancer (topical)

9. bleomycin Breaks DNA via oxidative intermediaries
Testicular cancer and hodgkin’s disease
Pulmonary fibrosis is dose-limiting

10. Alkylating agent gastric and pancreatic cancer
mitomycin
Alkylating agent
gastric and pancreatic cancer

11. Thymidylate synthase inhibitor Metastatic colorectal and breast cancer
capecitabine
Thymidylate synthase inhibitor
Metastatic colorectal and breast cancer

12. Topoisomerase II inhibitor Leukemias and lymphomas Watch heart failure
doxorubicin
Topoisomerase II inhibitor
Leukemias and lymphomas
Watch heart failure

13. hydroxyurea Inhibits ribonucleotide reductase
Hematologic malignancies, head & neck cancers, sickle cell (increases HbF)
Watch out for secondary leukemia

14. Alkylating agent Brain cancer
carmustine
Alkylating agent
Brain cancer

15. 6-MercaptoPurine Inhibitor of IMP dehydrogenase (purine construction)
ALL, AML
Allopurinol potentiates effectiveness and pancreatic/marrow toxicity

16. azathioprine Inhibitor of IMP dehydrogenase (purine construction)
Immunosuppression in renal transplants, RA
Allopurinol potentiates effectiveness and toxicity

17. etoposide Topoisomerase II inhibitor Testicular and lung cancer
Watch myelosuppression

18. Alkylating agent Ovarian cancer
altretamine
Alkylating agent
Ovarian cancer

19. Alkylating agent Bladder cancer (instilled directly into bladder)
thiopeta
Alkylating agent
Bladder cancer (instilled directly into bladder)

20. vincristine Prevents microtubule polymerization
Leukemias and Hodgkin’s disease
Peripheral neuropathy is dose-limiting

21. Adenosine analogue Hairy cell leukemia, MS
cladribine
Adenosine analogue
Hairy cell leukemia, MS

22. Cross-links guanines Genitourinary & lung cancer
carboplatin
Cross-links guanines
Genitourinary & lung cancer

23. Inhibits microtubule depolymerization Ovarian and NSC lung cancer
paclitaxel
Inhibits microtubule depolymerization
Ovarian and NSC lung cancer

24. topotecan Topoisomerase I inhibitor
Small cell lung cancer and cervical carcinoma
Beware life-threatening diarrhea

25. cisplatin Cross-links guanines Genitourinary & lung cancer
Watch nephrotoxicity; co-admin amifostine

26. Inhibits microtubule depolymerization Breast and gastric cancer
docetaxel
Inhibits microtubule depolymerization
Breast and gastric cancer