1. NM 4103 Section 4 Radiopharmaceutical Characteristics

2. 99m Tc Sodium Pertechnetate Eluted from 99 Mo generator Tested for 99 Mo and Al breakthrough Can be used for preparation of 99m Tc-labeled radipharmaceuticals (kits) or Used to image Thyroid and Meckel’s diverticulum (without mixing in a kit)

3. 99m Tc Macroaggregated Albumin (MAA) Preparation: – Heating HSA – Wash particles Particles – Number: 1-12 million particles per mg – Shape: irregular – Size: 10-90 µ m Checked for particle size Vial and syringe should be aggitated Used for lung perfusion imaging

4. 99m Tc Phosphates (MDP, HDP) Kit Preparation: – Add 99m Tc to kit, mix Weak chelates and tend to degrade with time – Prevented with tin and antioxidants Used for bone imaging

5. 99m Tc Sulfur Colloid Preparation: – Add acid – Heat in water bath Particles – Size: 0.1 to 1 µ m Larger particles could be trapped in the lungs Used for imaging liver/spleen, bone marrow, lymphoscintigraphy, GI bleed, and gastric emptying.

6. 99m Tc Pentetate (DTPA) Preparation – Add 99m Tc to kit, mix Used for renal and aerosol lung imaging.

7. 99m Tc labeled Red Blood Cells Preparation – In Vitro Method (Ultratag® kit) Draw blood, add to vial of stannous citrate/acid citrate dextrose(acd). Add sodium hypochlorite. Add ACD. Add 99m Tc and incubate. – In Vivo Method Sn 2+ injected into patient. Wait 20 minutes, then 99m Tc injected into patient Used to image GI bleed, liver hemangioma, gated blood pool (MUGA)

8. 99m Tc Iminodiacetic Acid (IDA) DISIDA (Hepatolite®) & Mebrofenin (Choletec®) Preparation – Add 99m Tc to kit, mix Used for hepatobiliary imaging.

9. 99m Tc Hexamethylpropylene Amine Oxime (Ceretec®) Preparation of 99m Tc HMPAO – Add 99m Tc to kit, mix Should be used within 4 hours of preparation. Used for brain imaging and labeling leukocytes

10. 99m Tc Sestamibi (Cardiolite®) Preparation – Add 99m Tc to kit – Heat in boiling water bath for 10 minutes. Used for imaging cardiac perfusion, parathyroid adenomas and breast tumors (Miraluma®).

11. 99m Tc Tetrofosmin (Myoview®) Preparation – Add 99m Tc to kit, mix and incubate for 15 minutes. Used for myocardial perfusion

12. 99m Tc MAG3 Preparation: – Add 99m Tc to kit – Add filtered air (to oxidize excess Sn 2+ ) – Heat in water bath for 10 min – Cool for 15 min Light sensitive Used for imaging renal function

13. 99m Tc Neurolite® Preparation: – Isotonic saline added to vial A – 99mTc added to vial B – Add vial A to B and incubate for 30 minutes Used for Brain perfusion imaging

14. 99m Tc DMSA Preparation: – Add 99m Tc to kit vial – Incubate for 10 minutes Light sensitive Used for renal cortical imaging

15. 99m Tc Gluceptate Preparation: – 99m Tc addto kit vial – Incubate for 15 minutes Used for renal imaging

16. 131 I Sodium Iodide Supplied in capsule or liquid Oral administration Used for thyroid uptake measurement and thyroid treatment

17. 123 I Sodium Iodide Cyclotron produced Capsule or liquid Oral administration Used for thyroid uptake measurement and thyroid imaging

18. 123 I or 131 I MIBG Preparation – 131 I and MIBG is refluxed for 72 hrs – Cooled – Passed through anion exchange column Used for imaging pheochromocytoma and for treatment of neuroblastoma

19. 111 In DTPA Preparation: – Adding dilute DTPA to solution of 111 InCl 3 in acetate buffer, pH 5 – Heat for 15 minutes in boiling water bath Used for cisternography and gastric emptying (liquid phase)

20. 133 Xenon Noble gas and is chemically inert Produced by fission of 235 U in the reactor Shelf life is 14 days after calibration Should be handled in a proper fumehood Used for ventilation lung imaging

21. 201 Tl Thallous Chloride Cyclotron produced Used for myocardial perfusion imaging

22. 111 In Labeled Leukocytes Blood is drawn – Heparin or ACD added as anticoagulant – Hetastarch added to enhance sedimentation Leukocytes are separated – Sedimentation, centrifuge, washing Labeled with 111 In Oxine Used for detecting infection or abscesses.

23. 99m Tc Labeled Leukocytes Blood is drawn – Heparin or ACD added as anticoagulant – Hetastarch added to enhance sedimentation Leukocytes are separated – Sedimentation, centrifuge, washing Labeled with 99m Tc HMPAO (Ceretec®) Used for detecting inflammation, abscess or other infections (also Chrohn’s disease)

24. 111 In Prostascint® Murine monoclonal antibody Preparation: – 111InCl3 added to vial – Incubate for 30 mintues – Filtered to remove particulate matter Used for primary or metastatic prostate cancer.

25. 111 In Petetreotide (OctreoScan®) Radiolabeled Peptide Preparation: – 111InCl3 added to reaction vial – Incubate for 30 minutes Used for neuroendocrine tumors – Carcinoids, gastrinomas, neuroblastomas, pituitary adenomas, medullary thyroid cancer