1. Growth Hormone (GH) Holly Farris

2. What Is It? 191-amino acid, single chained polypeptide 191-amino acid, single chained polypeptide Synthesized, stored, and secreted by somatotrophic cells Anterior Pituitary gland

3. Function Increased height in childhood and adolescents –most known effect Increases mineralization of bones Muscle mass Stimulates growth of internal organs- excluding the brain Immune system

4. Positive or Negative? Negative High blood levels of IGF-I leads to decreased secretion of GH High blood levels of IGF-I leads to decreased secretion of GH IGF-1 directly suppresses the somatotrophic cells IGF-1 directly suppresses the somatotrophic cells

5. Hyper Gigantism- excessive growth, usually in childhood Most common Pituitary Tumor - causes headaches, impair vision by pressure on the optic nerves Pituitary Tumor - causes headaches, impair vision by pressure on the optic nerves

6. Hypo In children: Growth failure Growth failure Short stature Short stature In adults: Increase in fat mass Increase in fat mass Decrease muscle mass, energy and quality of life Decrease muscle mass, energy and quality of life