1. Aulani " Biokimia" Presentation2 Introduction to Metabolism Introduction to Metabolism Aulanni’am Biochemistry Laboratory Chemistry Departement Brawijaya University

2. Aulani " Biokimia" Presentation2 Metabolism Definition ? Definition ? Metabolic pathways = network of linked reactions Metabolic pathways = network of linked reactions Metabolism Metabolism Catabolism (ATP production) Catabolism (ATP production) Anabolism (Synthetic pathways) Anabolism (Synthetic pathways)

3. Aulani " Biokimia" Presentation2 PROTEINPOLISAKARIDALIPID BIOMOLEKU L ASAMAMINO GLUKOSA GLISEROL AS. LEMAK MOLEKULPEMBANGUN PIRUVAT ASETIL-KoA Tahap II Tahap I Tahap III PRODUKPEMECAHANUMUM PRODUKKATABOLISMESEDERHANA CO2H2ONH3 SIKLUS ASAM SITRAT PENTOSAHEKSOSA

4. Aulani " Biokimia" Presentation2

5. Metabolism of Energy Containing Nutrients CarbohydratePyruvate Acetyl CoA Krebs Cycle Protein Amino Acids Fat Fatty Acids Glycerol

6. Aulani " Biokimia" Presentation2 Biochemical Pathways

7. Aulani " Biokimia" Presentation2 How Cells Use Energy Adenosine Triphosphate (ATP) is the molecule in cells that supplies energy. Adenosine Triphosphate (ATP) is the molecule in cells that supplies energy. Five-carbon sugar (ribose) Five-carbon sugar (ribose) Adenine (nucleotide base) Adenine (nucleotide base) Chain of three phosphate groups Chain of three phosphate groups Most energy exchanges in cells involve cleavage of the outermost phosphate bond, converting ATP into ADP and inorganic phosphate. Most energy exchanges in cells involve cleavage of the outermost phosphate bond, converting ATP into ADP and inorganic phosphate.

8. Aulani " Biokimia" Presentation2 ATP-ADP Cycle

9. Aulani " Biokimia" Presentation2

10. Kinetic Energy Energy in the process of doing work. Energy in the process of doing work. Energy of motion. Energy of motion. Examples: Examples: 1.Heat 2.Light energy SUN

11. Aulani " Biokimia" Presentation2 Potential Energy Energy that matter occupies because of it’s location, arrangement, or position. Energy that matter occupies because of it’s location, arrangement, or position. Energy of position. Energy of position. Examples: Examples: 1.Water behind a dam 2.Chemical energy (gas) GAS

12. Aulani " Biokimia" Presentation2 Hydrolysis of ATP ATP + H 2 O  ADP + P (exergonic) ATP + H 2 O  ADP + P (exergonic) Hydrolysis (add water) PPP Adenosine triphosphate (ATP) PP P + Adenosine diphosphate (ADP )

13. Aulani " Biokimia" Presentation2 Dehydration of ATP ADP + P  ATP + H 2 O (endergonic) Dehydration synthesis (remove water ) (remove water ) PPP Adenosine triphosphate (ATP) PP P + Adenosine diphosphate (ADP )

14. Aulani " Biokimia" Presentation2