1. Lab A: Vincent Lindsay, Cyril Nicolas, Pascal Cérat and Sébastien Goudreau Synthesis Meeting Proposed Total Synthesis of Haliclonin A November 7 th, 2009

2. 2 Retrosynthesis

3. 3 Phosphonate: Tet. Lett. 1991, 32, 5907 Synthesis of Diels-Alder Precursors HWE: Paintner, F.F.; Bauschke, G.; Polborn, K. Tet. Lett. 2003, 44, 2549

4. 4 Diels-Alder

5. 5 Quaternary Center

6. 6 Macrocyclisation

7. 7 2nd Macrocycle Chain

8. 8 vinyl bromide: Tet. Lett. 2004, 45, 2563

9. 9 Addition of the 2nd Macrocycle Chain

10. 10 Macrocyclisation & Epoxydation

11. 11 Double Bond: Radical Deoxygenation-Epoxyde Opening

12. 12 Epoxyde Opening favorednot favored

13. 13 Final steps 27 steps

14. 14 Retrosynthesis

15. 15

16. 16 Epoxyde Opening favorednot favored