1. Life Sciences Trend Analysis 2013 CANADA

2. About Us The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology, Pharmaceutical and Medical Device industries. www.biotechgate.com www.biotechgate.com The Canadian Life Sciences Database is a part of the global Biotechgate and is brought to you in partnership with BIOTECanada, the national non-profit association dedicated to building the bio-based economy in Canada. www.canadianlifesciences.com www.canadianlifesciences.com Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.comwww.venturevaluation.com

3. Status of the Sector 2012 Statistics Canada 2013 Statistics 615Total Biotech Companies632 152Biotech - Therapeutics159 202Biotech - R&D Services201 261Biotech - Other272 91%Percentage of SME's89% 15%Percentage of Publicly Owned Companies14% USD 162 M in 2011 Financing/Capital Raised USD 67 M in 2012 190Licensing Opportunities175

4. Key Activities of Biotechnology Companies Historical Data Subsector20132012 AgroBio9% Environment12% Contract Research & Manufacturing 9% Diagnostics and Analytical Services 11%12% Food & Nutraceuticals6% Other Services and Suppliers20%21% Therapeutics14% Other19%17%

5. Company Foundation Timeline

6. Company Ownership Historical Data Subsector20132012 Private/ Independent76% Public14%15% Subsidiary10%9%

7. Sources of Company Foundations Historical Data Company Foundation20132012 Independent foundation54%70% Merger1%2% Spin-off from company1%2% Spin-off from public institution / NPO1%2% Spin-off from university5%7% Subsidiary9%13% Other3%4%

8. Number of Employees Historical Data No. of Employees20132012 1-1035%28% 11-5037%42% 51-20017%21% Greater than 20011%6%

9. Products in the Pipeline

10. Financing Rounds in Canada & 3 Major Financing Rounds Financing for 2012/2013 Private Biotech Companies Major Financings in 2012/2013SectorUSD M Thrasos Therapeutics, Inc. Biotech – Therapeutics & Diagnostics 35 Zymeworks Inc. Biotech – Therapeutics & Diagnostics 11 Plantform Corporation Biotech – Therapeutics & Diagnostics 10

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12. Terms of Use The “Canada Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof. The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions. Biotechgate c/o Venture Valuation VV AG Kasernenstrasse 11+41 (43) 321 86 60 8004 Zurichinfo@venturevaluation.com Switzerlandwww.venturevaluation.com