1. BBS3027 2000: Infectious Diseases Dr Garwin Sing garwinS@qimr.edu.au http://trishul.sci.gu.edu.au/courses/bbs3027/

2. Gut Mucosa

4. Mucosal Epithelium

5. Epithelial Barriers to Microbial Infection: Physical Epithelial cells joined by tight junctions Exfoliation of surface cells Mucous flow by ciliated epithelia (respiratory tract)

6. Epithelial Barriers to Microbial Infection: Chemical Enzymes: Lysozyme (tears, saliva, sweat) Pepsin (stomach) pH:Fatty Acids/amino acids (skin) Gastric acids (stomach) Antimicrobial:Transferrin (mucus)

7. Epithelial Barriers to Microbial Infection: Competition Gut Flora

8. Protection from Infectious Agents Innate ImmunityFever, interferon, neutrophils, macrophages, NK cells Adaptive ImmunityB cells, T cells

9. Congenital Infections

10. Viruses Bacteria Fungi Parasites Anatomy Physiology Immunity Commensals

11. Sources of Infection: Exogenous InhalationCommon cold, flu, Legionnaire’s Disease, Coccidioidomycosis IngestionTyphoid fever, tapeworm, cryptosporidium, Hepatitis A STDGonorrhea, HIV WoundTetanus, Rabies Insect BiteMalaria, Yellow Fever, Dengue

12. Sources of Infection: Endogenous Gute.g E coli Skine.g. staphylococcus Tonsils Throat e.g streptococcus Bloode.g. EBV Lungse.g Candida, CMV, streptococcus