1. Side effects of anti-TB medications HREZ

2. Isoniazid Isoniazid-induced hepatitis-most common major toxic effect
Peripheral neuropathy
CNS toxicity-memory loss, psychosis,seizures
Fever and skin rashes
Drug-induced SLE
Hematologic abnormalities
Provocation of pyridoxine deficiency anemia
Tinnitus
Gastrointestinal discomfort
Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 773

3. Rifampicin Orange urine, sweat and tears Rashes Thrombocytopenia
Nephritis
Light-chain proteinuria
Flu-like sydrome(fever, chills, myalgia, anemia and thrombocytopenia)
Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774

4. Ethambutol Retrobulbar neuritis
most common serious adverse event
Loss of visual acuity and red-green color blindness
Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis)
Fever and lymphadenopathy
Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774

5. Pyrazinamide Hepatotoxicity-major adverse effect Nausea Vomiting Fever
hyperuricemia
Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775

6. *Streptomycin Vertigo and hearing loss nausea, vomiting
paresthesia of face
rash
fever
Urticaria
angioneurotic edema
eosinophilia
Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775