1. Tiamulin 45% Sintofarm W.S.P
(tiamulin hidrogen fumarate)

3. FEED COMPOSITION
FEEDING PROGRAMS AND FEEDING COMPOSITION ARE IMPORTANT FACTORS THAT PREDISPOSE LIVESTOCK TO ANIMAL DISEASE. -

4. Tiamulin is a semisintetic antibiotic with potent activity against pathogenic mycoplasma organisms, a large number of gram-positive and some-negative organisms 4

5. Tiamulin 45% Sintofarm W.S.P
Mycoplasma :
M. hyopneumoniae ,
M. hyorinis ,
M. hyosynoviae
Spirochetes :
Brachyspira hyodysenteriae (serpulina,treponema)
Campylobacter spp.
Leptosoira spp.
Mycoplasma :
M. hyopneumoniae ,
M. hyorinis ,
M. hyosynoviae
Spirochetes :
Brachyspira hyodysenteriae (serpulina,treponema)
Campylobacter spp.
Leptosoira spp. 5

6. Tiamulin 45% Sintofarm W.S.P
Gram-positive:
Staphylococcus spp.
Streptococcus spp.
Erysipelothris spp.
Clostridium spp.
Gram-negative :
Haemophilus spp.
Actinobacillus spp.
Campylobacter (vibrio) coli .
Pasteurella spp. 6 6

8. Tiamulin 45% Sintofarm W.S.P
Mode of action:
Achieves bacteriostatic effect by interfering with microbial protein metabolism.
Absorption
Rapidly absorbed from alimentary tract. Maximum blood level achieved hours after oral administration.

9. Tiamulin 45% Sintofarm W.S.P
Combinations :
Tiamulin is compatible with tetracyclines, sulfas, imidazoles, and common feed additives.
Palatability :
No "medicinal taste" to deter sick animals from eating or drinking.
Reproductive failure in swine can have either infectious or noninfectious etiology. 9 9

10. Tiamulin 45% Sintofarm W.S.P
Warning :
Pigs and poultry should not receive products containing ionophore antibiotics (salinomycine, monensin, ecc.) during treatment with tiamulin.
Causes:
Inadeguate hygenic conditions
hormonal stress factors
infrequent urination
Anions cations diet imbalance
Effects:
imbalance of the normal microflora of the urogenital tract, enabling commensal organisms to become pathogens
Less piglets born alive
Increase returns to estrus
Sows mortality
Increase in MMA (Mastitis-Metritis-Agalactia Syndrome) predisposition 10

11. Tiamulin 45% Sintofarm W.S.P
Tiamulin 45% W.S.P. is :
For treatment of : swine dysentery, swine enzootic pneumonia , CDR (chronic respiratory disease) in poultry, swine and poultry mycoplasma arthritis .
For improving feed efficiency and weight gain.
Safety:
absorbed quickly and completely , no problem of resistance , no dusting problem , low residues and clear rapidly.
Efficient:
best product for treatment and rapid control of mycoplasma and bacterial infections in pigs and poultry.
Proper hygiene
Proper facility design
Ensurance of adequate water intake
Minimization of sedentary behavior
Immunitary stimulation
Regulation of urinary pH
Regulation of intestina microflora 11

12. Tiamulin 45% Sintofarm W.S.P
Tiamulin 45% W.S.P. is :
powder with 45% active ingredient (THF) on lactose.
W.S.P. Medicated premix soluble powder. Composition Active principle:
Thiamuline hydrogen fumarate 450 g corresponding to Thiamuline 360 g
Carriers: up to 1000 g. 12 12

13. Tiamulin 45% Sintofarm W.S.P
Indications:
Broilers: Mycoplasmosis, Cronic respiratory diseases, Infectious arthritis.
Swine: Mycoplasmosis, Enzootic pneumonia, Swine dysentery.
Method of administration : oral administration.
The product is to previously dissolved in drinking water.
Dosage and indicative period of treatment :
275 – 555 g / ton of drinking water for 3-5 days 13 13

14. Tiamulin 45% Sintofarm W.S.P
Swine for prevention of SD 0,5 g of product each 100 kg of live weight for 6 week .
Swine for therapy of SD 1,5 g of product each 100 kg of live weight for 3-5 days.
Broilers g of product each 100 kg of live weight for 3-5 days.
Sinovitis Tarsal
Bursitis pectoral