1. Manifestations: Embolism Pulmonary artery with septic emboli in the lumen. These are composed of bacterial clump seen as purplish granules mixed with fibrin When septic emboli lodged, infectious agent can spread out of the vessel causing regional infection resulting in tissue destruction and inflammatory response.

2. Manifestations: Janeway lesions These are painless hemorrhagic cutaneous lesions on the palms and soles. They are non-tender, small erythematous or hemorrhagic macular or nodular lesion, only a few millimeters in diameter that are pathognomonic of infective endocarditis, which is due to the deposition of circulating immune complexes in small blood vessels

3. Manifestations: Splinter haemorrhages They are tiny lines that run vertically under nails. In certain conditions (in particular, infective endocarditis), clots can migrate from the affected heart valve and find their way into various parts of the body. If this happens in the finger, it can cause damage to the capillaries resulting in a splinter haemorrhage.

4. Manifestations: Intracranial hemorrhage

5. Manifestations: Conjunctival hemorrhage