1. Reaqua BT99

2. 1.Reaqua BT99
Reaqua BT99 is a betaine,betaine is discovered by the Scheibler, and separated from the sugar beet, It is a completely natural, edible amino acids. Since 1939, DU Vigneaud found its nutritional function,it has become a hot topic of research, and is widely used in the pharmaceutical, food, additives, chemical reagents, chemical raw materials, livestock breeding, aquaculture and other fields.

3. Chemical structure： The Physical properties of Reaqua BT99
❀White crystalline powder
❀Sweet and bitter taste
❀Soluble in water, ethanol, PG and glycerin
❀Solubility:
160g Reaqua BT99 / 100g water
8,7g Reaqua BT99 / 100g ethanol
slightly soluble in ether
❀Compatible with anionic, cationic and nonionic materials
❀High temperature resistant
❀Heated to 310°decomposition
❀Loss on drying(105℃, 2 hours) ≤1.0%
❀Reaqua BT99 Content ≥99.0%
❀Residue on ignition ≤0.1%
❀PH Value (5%)
❀Sulphate ≤20 ppm
❀Heavy metal(Pb) < 10 ppm
❀Arsenic < 2 ppm
The Physical
properties
of Reaqua BT99

4. 2.The function of Reaqua BT99
2.1 Reaqua BT99 is a major osmolyte K+
Sugars
Amino Acids
Reaqua BT99
H2O
Water follows osmotically active compounds such as potassium and organic osmolytes
Water doesn`t move alone

5. Disturbance
Original cell volume
Swell
Shrink
Recovery
Osmolyte efflux
Osmolyte uptake
Cells regulate their volume and water balance by absorbing or effluxing osmolytes

6. 2.2 Maintain moisture balance
Water is common base to
all biological solutions and
thus to life itself
All cells are 85-95% water
Reaqua BT99 attracts water but does not immobilize it as a moisturizer

7. 2.3 Solubilization of insoluble material, such as salicylic acid and allantoin
Use levels from 2 to 10 %.
Solubility in water is 0.2 % at room temperature
Reaqua BT99 was found to increase the solubility of salicylic acid to 5 %
Allantoin
-solubility in water 0.7 % at RT
-Reaqua BT99 was found to increase the solubility of allantoin
to 2 %

8. 2.4 Buffering properties of Reaqua BT99
pH values after addition of HCl 1N to 100 mls of 1M Reaqua BT99 aqueous solution

9. 2.5 Polymers swelling Viscosity values during the swelling phase of
1% water and water-
Reaqua BT99 dispersions
of Sodium
carboxymethylcellulose
0,14% Na CARBOMER aq

10. 2.6 Reaqua BT99 ability to reduce the irritating effects of detergents
Human patch test SLES/Reaqua BT99 on 25 volunteers
1. Test solution:
10.3 % SLES
0 - 7 % Reaqua BT99
2. 25 µL of the test solution was applied on the forearm in a „Finn chamber“
(sealed Al-chamber)
3. Removal of the Finn chamber after 24 and 48h, respectively.
4. Dermatologists assessed
skin irritation 1 hour after
removal

11. 8424 11

12. Inositol, & Taurine uptakes
2.7 Osmotic Stress : UV radiation
Oxidative Stress
Opening of K+ channels
Cell shrinkage
Increased Reaqua BT99, Inositol and Taurine transporters & uptake
Increased Reaqua BT99,
Inositol, & Taurine uptakes
(Warskulat et al. 2004)
Inositol
Reaqua BT99
Taurine

13. 2.8 Sensory properties
Reaqua BT99 modifies the feel of aq. Solutions and emulsions with 3-4 %
❀Glycerol
❀Sorbitol
❀Propylene glycol
Best performer
❀50/50 glycerol/ Reaqua BT %

14. 2.9 Improving the performance of foam
Foam texture when 0% Reaqua BT99 included
Foam texture when 5% Reaqua BT99 included

15. Thank you！