1. Presented By : Mahgul Gulzai (0612112)

2.  Introduction  History  Types of Artificial Heart  Why do we need Artificial Heart  Artificial Heart Surgery  Risk factors of artificial heart surgery  Benefits  Role in Bioinformatics  Role in Pakistan

3. Definition  An artificial heart is the long term replacement of the Original heart, if the heart does not work properly. It is implanted in human body to replace the biological heart.  Also known as “ventricular assist devices (VADs) or TAH”

4.  Dr. John Heysham Gibbon  Heart-lung machine  Harper University Hospital (Sep 29, 1903 – Feb 5, 1973)

5. AbioCor  The AbioCor is the artificial heart is developed by Abiomed.The AbioCor heart, which is composed of titanium and plastic, connects to four locations:  Right atrium  Left atrium  Aorta  Pulmonary artery

7. Jarvik 7  Robert Jarvik, MD is widely known as the inventor of the first successful permanent artificial heart, the Jarvik 7.  In 1982, the first implantation of the Jarvik 7 in patient Barney Clark caught the attention of media around the world.

8. There are two reasons that we need TAH:  It stays you alive while you wait for transplant.  You may benefit from a total artificial heart (TAH) if both of your ventricles don't work due to end-stage heart failure.

10. The risks for surgery include:  Bleeding  Infection  Heart attack  Irregular heartbeat  Diseases :Cancer, kidney failure, Multi- organ failure etc.

11.  If your both ventricles are not working.  If you're waiting for a heart transplant, a TAH can help you survive longer.  It also can improve your quality of life.

12.  Maintain model of the pump and patient continuously evaluates the available estimates of variables.  The Machine Evaluate the status and history of Patient, validity of Information.  Supervisor of the Surgery uses optimization algorithm to determine the reference speed.  It also estimates the operating status of artificial heart.  It is used to calculate total protein level of patient before, after and during the implantation of artificial heart. And also diagnose heart disease through Machine.  Changing the pumping speed of the heart to handle your changing activity levels

13.  Heart disease has appeared as the main cause of death in Pakistani rural as well as in urban areas.  These devices are used in Jinnah Postgraduate Medical Centre (JPMC).  According to the survey conducted by WHO in April 2004: Site (Area)Survey type Population size (Age) Sex Sindh (urban and rural) Community20–80Male (urban)Community30–60Both (urban)School5–15Both (urban)School5–15Both

14.  On October 27, 2008, French professor and leading heart transplant specialist Alain F. Carpentier announced that a fully implantable artificial heart will be ready for clinical trial by 2011 and for alternative transplant in 2013.

15. Thank You