1. Special Article Adolescent Overweight and Future Adult Coronary Heart Disease Kirsten Bibbins-Domingo, Ph.D., M.D., Pamela Coxson, Ph.D., Mark J. Pletcher, M.D., M.P.H., James Lightwood, Ph.D., and Lee Goldman, M.D., M.P.H. N Engl J Med Volume 357(23):2371-2379 December 6, 2007

2. Study Overview Obesity, which is increasingly common among adolescents, is a risk factor for coronary heart disease (CHD) In this report, modeling the effects of overweight and obesity in adolescents on the risk of future CHD projects a substantial increase in the number of cases in the future

3. Projected Changes in Cardiovascular Risk Factors per 1-Point Increase in the Body-Mass Index (BMI) Bibbins-Domingo K et al. N Engl J Med 2007;357:2371-2379

4. Estimated Prevalence of Cardiovascular Risk Factors among 35-Year-Old Men and Women in 2020, According to the Presence or Absence of a Projected Increase in Adult Obesity Associated with Adolescent Overweight Bibbins-Domingo K et al. N Engl J Med 2007;357:2371-2379

5. Annual Excess Coronary Heart Disease (CHD) Events from 2020 to 2035 Associated with Three Projections of Future Adult Obesity Bibbins-Domingo K et al. N Engl J Med 2007;357:2371-2379

6. Prevalence of Coronary Heart Disease (CHD) Associated with Three Projections of Future Adult Obesity Bibbins-Domingo K et al. N Engl J Med 2007;357:2371-2379

7. Effect of Treatment for Obesity-Related Risk Factors for Coronary Heart Disease (CHD) on Annual Excess CHD Events from 2020 to 2035 Associated with Future Adult Obesity Bibbins-Domingo K et al. N Engl J Med 2007;357:2371-2379

8. Conclusion Although projections 25 or more years into the future are subject to innumerable uncertainties, extrapolation from current data suggests that adolescent overweight will increase rates of CHD among future young and middle-aged adults, resulting in substantial morbidity and mortality