1. Family Secrets Problem Based Learning

2. Family Secrets Part 1: A Family Disease Part 2: The Test Part 3: A Difficult Choice Part 4: Testing for the HD Gene Part 5: Making Decisions

3. Team Roles Secretary Recorder Spokesperson

4. In Part I, you will  Learn about a family with a history of a genetic disease.  Listen to a short reading.  Make lists of Facts and Questions.  Practice brainstorming rules.

5. Class read aloud Part 1: “A Family Disease” Listen to reading On the sheet provided write Facts that you know from the reading Develop Questions that you have

6. Family Secrets Part 2, you will  Read another short narrative  List new Facts and Questions  Categorize Questions

7. Family Secrets Groups have 1 minute to go over the case of the Lanahan Family What is the dilemma?

8. Categorize Questions Risks and Cause (RC) Symptoms and Prognosis (SP) Diagnosis and Treatment (DT) Family Issues (not researchable) (FI)

9. Topical Barometer If you were Jenny, would you have genetic testing for Huntington’s disease? Put your dot on the Topical Barometer continuum. ________________________________________________ Definitely Maybe Not Sure Maybe Definitely Yes Yes No No

10. Teams organize for research Assign each team member a different category of Questions Each team member will become a “Category Specialist” Write the heading of your category on the Individual Research Log

11. Jigsaw 1  Category Specialists meet in groups to share research  Specials go back to their groups and share information Diagnosis And Treatment Family IssuesRisks and Cause Symptoms And Prognosis

12. Huntington Gene on chromosome 4

13. Family Secrets Part 3 A Difficult Choice

14. Class read aloud Part 3: A Difficult Choice Class read aloud Part 3: A Difficult Choice Listen to reading Make a List of the Facts

15. An Ethical Issue or Dilemma …. a situation that requires a decision or an action that involves competing ethical principles and values. …. a situation that requires a decision or an action that involves competing ethical principles and values.an

16. Rank each principle in order of importance to you  Right to decide (Autonomy)  Do what is best (Beneficence)  Do no harm(Nonmaleficence)  Do what is fair (Justice)

17. Rank your “top 3” values  Actions to relieve the suffering of others Compassion  Keeping a secret Confidentiality  Keeping a promise; fulfilling an obligation Fidelity  Treating others as you would like to be treated Golden Rule  Telling the truth Honesty  Conforming to your own ethical principles/moral values Integrity  Keeping from public view Privacy  Preserving the dignity of self and others Respect

18. Ethical Decision-Making Process: By yourself…. Based on the chart and the ethical principles and values that are important to you…. Based on the chart and the ethical principles and values that are important to you…. What do you think is the best course of action?

19. Modified Topical Barometer #2 If you were Jenny, would you have genetic testing for Huntington’s disease? ________________________________________________ DefinitelyDefinitely Yes No Yes No

20. Reflection Questions Barometer Conclusions and Conversation: What conclusions would you make after seeing both Huntington Disease: What is it Topical Barometers? If you shifted your position on the Topical Barometer, explain why.

21. Homework Have students read and fill out the Informed Consent Form

22. Part 4: Lab Powerpoint Gel Electrophoresis Family Secrets Copyright © 2004, University of Rochester

23. Agarose Gel

24. DNA

25. DNA and Electrical Current

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30. Part 5 The Future Fill out the Genetic Testing Laboratory Report – discuss results Read Part 5 Scenario Discuss the future for the Lanahan Family