2. Sensor Sensor Optimization

3. for internal use only Normal chronotropic response 60 70 80 90 100 110 120 130 140 150 Rate min -1 Time

4. for internal use only Chronotropic incompetence 60 70 80 90 100 110 120 130 140 150 Rate min -1 Time

5. for internal use only Chronotropic incompetence 60 70 80 90 100 110 120 130 140 150 Rate min -1 Time

6. for internal use only Chronotropic incompetence 60 70 80 90 100 110 120 130 140 150 Rate min -1 Time

7. for internal use only Omnisense Accelerometer In the following products: Trilogy DR+ Affinity Entity Integrity Identity ADx-family

8. for internal use only Omnisense Accelerometer

9. for internal use only First Clinical Experience with a new accelerometer-based Sensor during different daily activities, Candinas R, Erne P, Schönbeck M, European Trilogy DR+ Investigators, EUR.J.C.P.E, 1996:6.177:A706 26/5 Omnisense (literature)

10. for internal use only Sensor Pacemakers Maximum Rate (Minimum Rate = Basic Rate) Threshold Slope (Rate responsive factor) Reaction time Recovery time Parameters

11. for internal use only Sensor Parameters

12. for internal use only Sensor Parameters

13. for internal use only Sensor Parameters

14. for internal use only Activity Level and Sensor Signal Z Z Z ZZ Z Z Z

15. for internal use only Mean Value Max Rate Min Rate Rate Activity Z Z Z ZZ Z Z Z Threshold AUTO -0.5 Sensor Threshold 60 70 80 90 100 110 120 50 40 Too low threshold: Sensor driven rate at rest! Too high threshold: Basic rate at low level exercise!

16. for internal use only Max Rate Min Rate Rate Activity Z Z Z ZZ Z Z Z Sensor Slope 60 70 80 90 100 110 120 50 40 Slope 8 Slope 8: This activity level gives a rate increase of 25 min -1

17. for internal use only Max Rate Min Rate Rate Activity Z Z Z ZZ Z Z Z Sensor Slope 60 70 80 90 100 110 120 50 40 Slope 12 Slope 12: The same activity level gives a rate increase of 40 min -1

18. for internal use only Max Rate Min Rate Rate Activity Z Z Z ZZ Z Z Z Sensor Slope, Basic Rate and Max. Sensor Rate 60 70 80 90 100 110 120 50 40 Slope 6 A low slope, a low basic rate or a high max. sensor rate may exclude ability to reach max. sensor rate.

19. for internal use only Slope and Target Rate Target Rate, slope 8 Target Rate, slope 12

20. for internal use only Reaction- & Recovery Time Reaction TimeRecovery Time

21. for internal use only 0128 80 90 100 110 120 130 140 70 60 Rate Sensor Slopes Max. Sensor Rate Threshold 1 2 3 4 5 6 7 8 910 111213141516

22. for internal use only

23. Diagnostics 39 94 6 6% 1% 29%<1%62%

24. for internal use only Heart Rate Histogram Histogram shows ventricular rate, preceded by AP or AS (or a PVC) …And for total time sampled

25. for internal use only Chronotropic Incompetence

26. for internal use only Is Sensor On or Passive?

27. for internal use only Mix of Sensor Drive & Intrinsic rate

28. for internal use only Intrinsic Rate Overdriving the Sensor

29. for internal use only Is Sensor Performing Well?

30. for internal use only Sensor On or Passive?

31. for internal use only

35. Rate Response Optimization

36. for internal use only