1. Beef IQ Herd Health – Vaccination & Disease Prevention Jeremy Powell, DVM, PhD Associate Professor University of Arkansas Dept. of Animal Science

2. Basic Principles of Immunology

3. TheImmune System System INNATE NOT antigen specific NO memory ACQUIRED Antigen specific Memory

4. Innate Immune System Physical barriers – skin, mm Chemical protection – tears, saliva, acid Primary cell types –Myeloid cells Neutrophils Eosinophils Basophils –Macrophages Measured by: Differential cell numbers Chemotactic activity Phagocytic activity

5. Acquired Immune System Cellular Immune Response –T lymphocytes T H T C Humoral Immune Response –B lymphocytes (Plasma cells) Longer Lasting Antibody production

6. Acquired Immunity Active immunity – Natural – Artificial Passive immunity

7. Biologicals and Pharmaceuticals

8. Biologicals – Made up of bacterins and vaccines – A bacterin/vaccine is a suspension of killed or weakened microorganisms Killed Vaccine – Has no self-replicating microorganisms Modified Live Vaccines – Contain microorganisms that have been weakened through culturing and laboratory procedures

9. Biologicals and Pharmaceuticals Pharmaceuticals: – Are medicinal drugs. – Contain no live or killed microorganisms – Are used to treat a variety of health related conditions – Almost every pharmaceutical has a withdrawal period – Example: Antibiotics such as LA-200

10. Types of Drug Use Labeled Use: Using the drug EXACTLY as it is specified on this label. Medicated feed may only be used as directed by the label. Labeled use is legal and the type of use most producers use! Off Label: The PRODUCER uses drugs on their own in a manner other than what is stated on the label without veterinarian guidance. This is ILLEGAL!! Extra Label: The VETERINARIAN prescribes a drug to be used in a manner other than whats on the label. This is legal and is used when a good veterinarian-client-patient relationship exists.

11. Vaccination Vaccination is a good protection tool Active immunity engaged through vaccinations with biologicals Vaccination is for prevention of disease – Prevention of disease is cheaper than treatment of disease

12. Points to Ponder Best Time to Vaccinate?? When do you need the most protection? Before disease exposure occurs – Takes 5-7 days for protection with most modified-live vaccines – Killed vaccines require a booster within 2-4 weeks of initial vaccination to obtain adequate protection levels Dont expect to vaccinate one day and get protection the next day

13. Points to Consider? What kind of vaccine? – Killed – Modified-Live – Autogenous Advantages vs. Disadvantages

14. Killed Vaccines Viruses, bacterins, toxoids – 1 st dose to sensitize – 2 nd dose to produce immunity Two doses required

15. Two dose response curve

16. Killed Vaccine Advantages – Does not replicate in the animal – Safer to use in pregnant animals Disadvantages – Most require boosters – Tissue irritation at vaccination site

17. Modified-Live Vaccines Advantages – Usu. requires one injection – Lower $$$, smaller dose – Less irritation at injection site – Longer immunity Disadvantages – May cause abortion in pregnant animals – Shouldnt use on calves nursing preg. cows – Stress from mild form of disease

18. Reasons for Vaccine Failure Human Error: – Not following directions on the label! – Disinfectant used on syringes – Mixing several products together – Vaccinating at the wrong time – interval

19. More Reasons for Vaccine Failure Vaccine Factors: – Improper storage of vaccine – Use and restore

20. More Reasons for Vaccine Failure Host Factors: – Some animals dont respond

21. More Reasons for Vaccine Failure Host Factors: – Severe challenge

22. Recommended & Optional Vaccines Vaccine & est. cost per head: – Recommended: – 5-Way (IBR, BVD, PI3, BRSV) = $1.50 (all) – Blackleg (7-way) = $0.45 (all) – Leptospirosis & Vibriosis = $0.75 (cows) – Optional: – Pasteurella = $2.20 (calves) – Scours = $3.20 (cows) – Pinkeye = $0.85 (all)

23. Why Precondition? Opportunity to profits Benefits Both Buyer and Seller – Seller will receive additional value on calves – Buyer realizes improved health and gain performance Improve the welfare of our cattle

24. Pre-Con Protocol Requirements differ between sales – Wean Vac vs. VAC 45 Process 2-4 wks before wean or at wean 5-way: IBR, BVD Types 1&2, PI-3, BRSV Blackleg – 7 way or 8 way Past./H.somnus Dewormer Castrating, dehorn Revac. in 2-6 wks.

25. Economics of Preconditioning Outcome of AR Precon Calf sales Cost & ReturnsValue/calf Gross Return$88.99 Death Loss- $0 Labor- $6.87 Veterinary Costs- $17.83 Other costs- $10.19 Hay/Feed/Mineral/Pasture- $33.10 Total Net Return$21.00