1. Lynelle Dequina Aashini Patel
Cri du Chat
Lynelle Dequina
Aashini Patel

2. How You Get this Disease
Caused by the deletion of a segment of chromosome 5; has missing piece on chromosome 5
causes more deletions of other genes
causes many of the symptoms related to this disorder
The chromosomes break while the sperm/egg is developing
The disease develops during fertilization

3. Genetics Continued Also called the 5p minus syndrome
Missing part of the “short arm” on chromosome 5
The size of the missing piece varies
The larger the segment lost: the more severe the symptoms
Usually this disease is NOT inherited
Mutation occur during fertilization
Rare cases when parent gives a mutated chromosome to the offspring
This leads to the deletion later

4. Symptoms Cry that sounds like a cat Mental retardation
High pitched
Because of the fact of the underdeveloped larynx
Slow development
Light weighted infant
Respiratory issues
Mental retardation
Small head (distinct facial features)
Far apart eyes
Ears are positioned lower
Little jaw
Round face
Heart defects
Difficulty walking/speaking
Hearing/seeing problems

5. Treatment & Prevention
Though there is no treatment for cri du chat, children can go through therapy to improve their language and motor skills.
There is no currently known method for prevention as well. Parents who have a balanced translocation associated with the disorder can go to genetic counselors who can help them understand the risks of having a child.

6. Cri du Chat History
The disorder was first identified by the French geneticist Jerome Lejeune in 1963.
In 80% of cases, the chromosome carrying the deletion came from the father instead of the mother.

7. Life with Cri du Chat
Children who have Cri du Chat may have eating problems, excessive drooling, chronic constipation, frequent ear infections, low/high muscle tones, plus many more.
Parents will have to schedule multiple therapies for their child in order to develop their skills.

8. Works Cited