1. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation Arshad jahangir, MD; Victor Lee, MBBS; Paul A. Friedman, MD; Jane M. Trusty, RN; David O.Hodge, MS; Stephen L. Kopecky, MD; Douglas L. Packer, MD; Stephen C. Hammil, MD; Win-Kuang Shen, MD; Bernard J. Gersh, MBChB, DPhil.

2. This study was conducted to: This study was conducted to: Investigate the potential predictors in patients with intermittent atrial fibrillation who progress to permanent atrial fibrillation. Evaluate the associated comorbidities and their implication in the progression and complications in patients with lone atrial fibrillation in relation to a similar matched population. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation: Objectives

3. 71 patients Paroxismal AFib (n=34) Persistent AFib (n=37) Persistent AFib (n=5) - excluded Median age 44  11 yr No SHD/no HTN Mean F-U 30 yr 71 patients Paroxismal AFib (n=34) Persistent AFib (n=37) Persistent AFib (n=5) - excluded Median age 44  11 yr No SHD/no HTN Mean F-U 30 yr 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation Jahangir, Friedman et al, Circ 2007

4. Natural History of Lone Atrial Fibrillation Jahangir, Friedman et al, Circ 2007 Cumulative Survival Survival from death (%) Expected Observed P=0.120 Years after diagnosis of AFib

5. CP1173154-1 Cumulative Survival Free of Stroke/TIA Years after diagnosis of AFib Survival free of stroke/TIA (%) Expected Observed P=0.014 Natural History of Lone AFib (Stroke/TIA) Jahangir, Friedman et al, Circ 2007

6. Cumulative Survival Survival from death (%) Expected Observed P=0.120 Years after diagnosis of AFib Cumulative Survival Free of Stroke/TIA Survival free of stroke/TIA (%) Expected Observed P=0.014 71 patients Median age 44  11 yr Paroxysmal AFib No SHD/no HTN Mean F-U 30 yr 71 patients Median age 44  11 yr Paroxysmal AFib No SHD/no HTN Mean F-U 30 yr Jahangir et al CP1173154-2 Expected Observed P=0.014 Age Development of hypertension Multivariate analysis Predictors of stroke/TIA Years after diagnosis of AFib Natural History of Lone AFib (Stroke/TIA)

7. Older age is an independent predictor of progression from paroxysmal to permanent lone atrial fibrillation, as well as an univariate predictor of increased mortality and cardiac mortality rates. Older age is an independent predictor of progression from paroxysmal to permanent lone atrial fibrillation, as well as an univariate predictor of increased mortality and cardiac mortality rates. Associated comorbidities influence the progression and risk of complications in patients with Atrial Fibrillation. Associated comorbidities influence the progression and risk of complications in patients with Atrial Fibrillation. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation: Conclusions