1. . © 2010 HaB International Ltd © 2011 POWERbreathe International Ltd

2. © 2010 HaB International Ltd POWERbreathe K-Series – The Product Range K2 K3K1 Consumer ProductsProfessional Healthcare KH1 Non-downloadable Real-time data logging K4K5KH2 © 2011 POWERbreathe International Ltd

3. . © 2010 HaB International Ltd POWERbreathe K-Series is a handheld electronic inspiratory muscle training device and is the third generation of POWERbreathe products It is used to generate a resistance to inhalation in order to train the muscles used to breathe (diaphragm and intercostal muscles) Variable resistance training is generated by a variable disk valve which moves up to 4000 times per second Resistance is controlled in response to measurements of pressure, flow and volume calculated up to 500 times a second The system allows training to be continuously and precisely controlled in response to different measurements Provides feedback and measurements on training progress and inspiratory muscle performance What is the POWERbreathe K-Series? © 2011 POWERbreathe International Ltd

4. © 2010 HaB International Ltd Length Tension Relationship Advanced Variable Resistance Training Tension Length Power Curve The relationship between the length of a muscle and the contractile tension that it can exert A muscle can usually exert its greatest contractile tension when it is at its resting length At resting length has most active force Typical length tension relationship © 2011 POWERbreathe International Ltd

5. © 2010 HaB International Ltd Tension Length Power Curve Start point of the bicep muscle weakest point Full length. Tension Length Power Curve Mid way point of the bicep muscle at is strongest. Tension Length Power Curve End point of the bicep muscle weakest point. Shortest length Advanced Variable Resistance Training © 2011 POWERbreathe International Ltd

6. © 2010 HaB International Ltd Start point of the breathing muscle strongest point when lungs are fully empty Mid way point of the breathing muscle End point of the breathing muscle weakest point Tension Length Power Curve Tension Length Power Curve Tension Length Power Curve Advanced Variable Resistance Training © 2011 POWERbreathe International Ltd

7. © 2010 HaB International Ltd The POWERbreathe K-Series creates a variable load which matches the length tension relationship of the inspiratory muscles allowing more effective training than conventional constant load training. 80% MIP RV IVC (Inspiratory Vital Capacity) RV (Residual Volume) IVC MIP 80% MIP MIP Advanced Variable Loading (POWERbreathe K-Series) Conventional Constant Loading (POWERbreathe Classic/Plus) vs Up to 50% more training work (area under graph) achievable at 80% intensity using variable load training Up to 125% more air inhaled per breath at 80% intensity using variable load training When constant loading is used, the breath must be stopped early as load starts to exceed inspiratory muscle strength Advanced Variable Resistance Training © 2011 POWERbreathe International Ltd

8. POWERbreathe K-Series Main Features © 2010 HaB International Ltd Pacing Guidance Session History Multiple Training Protocols Auto Setup Single breath Test © 2011 POWERbreathe International Ltd

9. Auto-optimising IMT © 2010 HaB International Ltd The POWERbreathe K-Series’ auto-optimising feature allows the device to automatically estimate the user’s ideal training resistance PIF MIP Inspiratory Muscle Force-Velocity Relationship Flow Pressure During the first two breaths of a session, the maximum value of flow, and the pressure at which it is measured, is recorded. Training resistance is extrapolated from the peak inspiratory flow using a typical inspiratory muscle force-velocity relationship. Training intensity can be adjusted when in the automatic set-up mode in order to suit the user’s tolerance to exercise. Alternatively, training load can be entered manually. © 2011 POWERbreathe International Ltd

10. Training Results © 2010 HaB International Ltd Training Results The POWERbreathe K-Series provides performance feedback following every training session Load is a measure of the resistance to inhalation during your training session – the equivalent to the weight lifted by the inspiratory muscles. Volume is the average volume of air inhaled per breath. Power is the average power generated during your entire training session and is a combined measure of the force exerted by the inspiratory muscles and the speed of contraction. Mechanical work (effort ) of breathing for the session. combines the force exerted by your inspiratory muscles and the volume of air inhaled Note: Feature only available for K4, K5, and KH2 model © 2011 POWERbreathe International Ltd

11. Single breath Test © 2010 HaB International Ltd The Strength Index test can be used to quickly assess inspiratory muscle strength at any time. The test calculates inspiratory muscle strength based upon the peak inspiratory flow during a single test breath. The test results also show the peak flow and inhaled volume from the test breath. These results can be used to monitor the effects of inspiratory muscle training. S-Index value is rated (from v.poor to excellent) based upon predicted normal values calculated using the profile information (age, height, weight and gender). PIF MIP Flow Pressure Note: Feature not available for K1 model Inspiratory Muscle Force- Velocity Relationship © 2011 POWERbreathe International Ltd

12. Single breath Test © 2010 HaB International Ltd S-Index Leader board 221 (UK) 202 197 195 183 165 138 (UK) 123 121 120 116 221 cmH20 © 2011 POWERbreathe International Ltd

13. Customise Training POWERbreathe K5 Features New feature K4, K5 and KH2 only BreatheLink Interface Patient Relational Database Pro-view Training © 2011 POWERbreathe International Ltd

14. Interfaces with Breathe-Link software via a USB port Real-Time live data sent 4000 times a second Allowing analysis, processing and graphically representation of real time live data Control the POWERbreathe unit via the PC POWERbreathe K5 Breathe-Link Interface © 2011 POWERbreathe International Ltd

15. Real time data acquisition analysis tool Advanced graphical plot High performance measurements of each individual breath POWERbreathe K5 Pro-view training © 2011 POWERbreathe International Ltd

16. Simplified View Snapshot of vital information POWERbreathe K5 Graphical view training © 2011 POWERbreathe International Ltd

17. Customisable Load with BreatheLink (K5) © 2010 HaB International Ltd Customise load for individual breaths Max number of breaths 60 Create your own training protocols Using the Breathe-Link software to upload to POWERbreathe K Series device © 2011 POWERbreathe International Ltd

18. . © 2010 HaB International Ltd Professional Healthcare Products © 2011 POWERbreathe International Ltd

19. © 2010 HaB International Ltd POWERbreathe KH1 and KH2 Professional Healthcare Models The POWERbreathe KH1 and KH2 are the next generation of inspiratory muscle training assessment tools for use by healthcare professionals including doctors, general practitioners, respiratory and cardiac specialists, surgeons, physiotherapists and nurses. KH1KH2 © 2011 POWERbreathe International Ltd

20. © 2010 HaB International Ltd Antibacterial Filter Adapter The POWERbreathe Kinetic KH1 and KH2 comes supplied with a filter adapter which enable use with TrySafe filters and other standard respiratory filters. This allows multi patient use of the same product whilst maintaining hygiene. POWERbreathe Kinetic – KH1 Additional Features Maximum Inspiratory Pressure Test The widely accepted standard test for inspiratory muscle strength. Patient inhales maximally against occluded valve from RV (Residual volume) The POWERbreathe Kinetic records the highest 1 second average pressure (50Hz sampling) No real census on how many breaths The maximum of three values that vary by less than 20% is recorded See ATS/ERS Statement on Respiratory Muscle Testing © 2011 POWERbreathe International Ltd

21. © 2010 HaB International Ltd PC Software In addition to the KH1 features the KH2 will also feature pc connectivity via USB cable. PC software will include the following features: POWERbreathe Kinetic – KH2 Additional Features Patient relational database management system Real-time data feedback Training customisation to suit patient groups Data will be in CVS format easily exported to Excel © 2011 POWERbreathe International Ltd

22. © 2010 HaB International Ltd POWERbreathe Kinetic KH1 and KH2 Healthcare Applications As a standalone mouth pressure (MIP) meter for the identification of respiratory muscle weakness Identifying appropriate training levels for the POWERbreathe Medic Monitoring the outcomes of IMT Familiarising the patient with the sensation of IMT Training a patient within the clinic Patient training in the home environment As a research tool for investigating IMT efficacy Potential Healthcare applications for the POWERbreathe Kinetic include: © 2011 POWERbreathe International Ltd

23. © 2010 HaB International Ltd POWERbreathe Kinetic – Basic Components © 2011 POWERbreathe International Ltd