1. VUOS COMPANY PROFILE PARTNER FOR COOPERATION

2. 2 22VUOS – PARTNER FOR COOPERATION Where you can find us

3. 3 33 VUOS – PARTNER FOR COOPERATION VUOS ownership AGROFERT HOLDING, a.s. SYNTHESIA, a.s. VUOS, a.s. 100%

4. 4 44 VUOS – PARTNER FOR COOPERATION History Foundation of Research Laboratories Voucher Privatisation New name – VUOS Affiliation of Synthesia´s R&D 100% daughter company of Synthesia a.s. 19921952 200419971941

5. 5 55 VUOS – PARTNER FOR COOPERATION VUOS main businesses 2. Toxicology and Analytics 1. R&D and Production of Fine Chemicals EmployeesSales in % 70 14 10 6

6. 6 6 The Certificates of VUOS Certificate ČSN EN ISO 9001: 2009 (organic chemicals - syntheses development and manufacture) Decision on Compliance with Principles of Good Manufacturing Practice in Control Laboratory Certificates of Good Laboratory Practice in Test Facility (OECD GLP Principles - 1997) Certificate of Accredited Certification Body for Certification of Products (EN 45011:1998) Certificate of Accredited Testing Laboratory (EN ISO/IEC 17025:2005) 6 VUOS – PARTNER FOR COOPERATION

7. 7 77 Strong Points Education structure of employees VUOS is located in area of long-lasting chemical tradition and complete infrastructure Cooperation with University of Pardubice Skilled – 25 % Secondary – 30% University degree – 36% Ph.D. degree – 9%

8. 8 88 VUOS – PARTNER FOR COOPERATION R&D, upscaling Pharmaceutical intermediates Intermediates for microelectronics Custom syntheses of chemical specialities Dyes and pigments for special application

9. 9 9 R&D, upscaling 9 VUOS – PARTNER FOR COOPERATION Wide range of quantities Grams – in laboratory Kilograms – in kilolab unit Metric tons – in VUOS production plant Hundreds of MT –

10. 10 VUOS ’s key chemistry VUOS ’s key technology 10 VUOS – PARTNER FOR COOPERATION Adamantane derivatives N-Heterocycles API Building Blocks Phosgenation Hydrogenation

11. 11 VUOS – PARTNER FOR COOPERATION VUOS ’s technology/manufacture expertise includes: acetylation aldolisation amidation alkylation amination amoxidation azocoupling benzoylation chiral synthesis chlorination chlorosulfonation Claisen condensation cross coupling reaction cyclisation decarboxylation elimination esterification Friedel-Crafts reaction Grignard reaction heterocyclic synthesis hydrolysis reactions neutralisation nitration nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride Sulfonation dehydrohalogenation diazotisation

12. 12 VUOS – PARTNER FOR COOPERATION Kilolab and Semi-Pilot Unit 2x reactors, 250 and 650 l 2x High performance rectification columns Laboratory phosgenation units from 1 to 30 litres Phosgenation

13. 13 VUOS – PARTNER FOR COOPERATION Kilolab and Semi-Pilot Unit 3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200 ˚C, Hastelloy C clad 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel 1x autoclave 1 000 l, 10 bar, 140 ˚C, stainless steel many autoclaves up to 10 l Hydrogenation

14. 14 VUOS – PARTNER FOR COOPERATION Kilolab Unit 1 x glass reactor 50 l cooled down to – 80 ˚C 1x glasslined reactor for NaH reactions (250 l) 3x glass reactors 100l for RLi, Grignard reactions Low temperature, RLi, RMgX, NaH

15. 15 VUOS – PARTNER FOR COOPERATION Kilolab and Semi-Pilot Unit 20x glass reactors, 100 l each 6x glass lined reactors (200–1 500 l) 2x evaporators 50 l / h 4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity Multipurpose chemistry

16. 16 45x glass lined reactors, total vol. 70 000 l (500–5 000 l) 13x stainless steel reactors, total vol. 22 000 l (1 000–3,000 l) 8x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled Production Equipment 16 VUOS – PARTNER FOR COOPERATION Production Unit

17. 17 VUOS – PARTNER FOR COOPERATION Toxicology, Ecotoxicology and Analytics

18. 18 VUOS – PARTNER FOR COOPERATION Toxicology, Ecotoxicology and Analytics REACH and CLP Services Literature search Preparation of dossiers in IUCLID 5 Preparation of Chemical Safety Report Non-testing approaches (Q)SAR Grouping/Read-across Preparation of SDS Classification of substances and mixtures

19. 19 VUOS – PARTNER FOR COOPERATION Analytical methods NMR Spectrometry Mass Spectrometry (LC/GC-MS) ICP-AES IR Spectrometry Chromatography (HPLC, GC) UV-VIS Toxicology, Ecotoxicology and Analytics

20. 20 VUOS – PARTNER FOR COOPERATION Toxicology, Ecotoxicology and Analytics Toxicological tests In vivo and in vitro tests according to the OECD or EU methods: Acute toxicity Skin and Eye irritation Sensibilisation Repeated dose toxicity Reproductive toxicity Carcinogenicity Mutagenicity

21. 21 VUOS – PARTNER FOR COOPERATION Toxicology, Ecotoxicology and Analytics Ecotoxicological tests Aquatic toxicity Biotic degradation Abiotic degradation Adsorption/desorption Physico-chemical tests Information on physicochemical properties of substance

22. 22 VUOS – PARTNER FOR COOPERATION Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550, fax: +420 46 682 2976 e-mail: karel.novak@vuos.com Sales Manager: Miloš Jesenský,Ph.D. Phone: +420 46 682 3300, fax: +420 46 682 2976 e-mail: milos.jesensky@vuos.com R&D: Alois Koloničný, Ph.D. Phone:+420 46 682 3156, fax: +420 46 682 3900 e-mail: alois.kolonicny@vuos.com Toxicology and Analytics: Viktor Mejstřík, Ph.D. Phone:+420 46 682 3127, fax: +420 46 682 2975 e-mail: viktor.mejstrik@vuos.com Process Engineering: Luboš Víšek Phone:+420 46 682 5790, fax: +420 46 682 3900 e-mail:lubos.visek@vuos.com

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